scholarly journals Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca 2+ transients in mouse vas deferens

2002 ◽  
Vol 541 (3) ◽  
pp. 849-862 ◽  
Author(s):  
Keith L. Brain ◽  
V. Margaret Jackson ◽  
Stephen J. Trout ◽  
Thomas C. Cunnane
Keyword(s):  
Smooth Muscle ◽  
Vas Deferens ◽  
Atp Release ◽  
Nerve Terminals ◽  
Mouse Vas Deferens

Varicosity-Schwann Cell Interactions Mediated by ATP in the Mouse Vas Deferens

2005 ◽  
Vol 93 (5) ◽  
pp. 2787-2796 ◽  
Author(s):  
Y. Q. Lin ◽  
M. R. Bennett
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Vas Deferens ◽  
P2y Receptors ◽  
Autonomic Nerve ◽  
Nerve Terminals ◽  
Metabotropic Receptors ◽  
Mouse Vas Deferens ◽  
Endogenous Release ◽  
Autonomic Nerve Terminals

Schwann cells, from a variety of sources, are known to possess P2Y purinergic metabotropic receptors. However, it is not known if Schwann cells associated with autonomic nerve terminals possess such receptors and if so whether these receptors are activated by the endogenous release of ATP from the nerve terminals. We show that such Schwann cells in the vas deferens give evoked calcium transients on nerve stimulation. These transients are mediated, at least in part, by the endogenous release of ATP, which acts on Schwann cell P2Y receptors to release calcium from within the cells. This work suggests the possibility that Schwann cells are active participants in the process of junctional transmission in the autonomic nervous system.

Tetrodotoxin-sensitive action potentials in smooth muscle of mouse vas deferens

1995 ◽  
Vol 52 (2-3) ◽  
pp. 237-240 ◽  
Author(s):  
Mollie E. Holman ◽  
Mary Anne Tonta ◽  
Helena C. Parkington ◽  
Harold A. Coleman
Keyword(s):  
Smooth Muscle ◽  
Action Potentials ◽  
Vas Deferens ◽  
Mouse Vas Deferens

Spatial relationships between sympathetic varicosities and smooth muscle cells in the longitudinal layer of the mouse vas deferens

1996 ◽  
Vol 25 (1) ◽  
pp. 413-425 ◽  
Author(s):  
L. J. Cottee ◽  
N. A. Lavidis ◽  
M. R. Bennett
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vas Deferens ◽  
Muscle Cells ◽  
Spatial Relationships ◽  
Mouse Vas Deferens ◽  
Longitudinal Layer

scholarly journals Some properties of the smooth muscle of mouse vas deferens.

1977 ◽  
Vol 266 (3) ◽  
pp. 751-764 ◽  
Author(s):  
M E Holman ◽  
G S Taylor ◽  
T Tomita
Keyword(s):  
Smooth Muscle ◽  
Vas Deferens ◽  
Mouse Vas Deferens

Spatial distribution and developmental appearance of postjunctional P2X1 receptors on smooth muscle cells of the mouse vas deferens

Synapse ◽  
2001 ◽  
Vol 42 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Simon Xun Liang ◽  
Leonard Motin ◽  
Charbel E.H. Moussa ◽  
Nickolas A. Lavidis ◽  
William Donald Phillips
Keyword(s):  
Spatial Distribution ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vas Deferens ◽  
Muscle Cells ◽  
Mouse Vas Deferens

scholarly journals Morphological studies of stimulated adrenergic axon varicosities in the mouse vas deferens.

1979 ◽  
Vol 80 (2) ◽  
pp. 310-325 ◽  
Author(s):  
C B Basbaum ◽  
J E Heuser
Keyword(s):  
Vas Deferens ◽  
Sympathetic Neurons ◽  
Recovery Process ◽  
Adrenergic Nerve ◽  
Nerve Terminals ◽  
Vesicle Membrane ◽  
Mouse Vas Deferens ◽  
Morphological Studies ◽  
The Mean

The postganglionic axons of sympathetic neurons innervating the mouse vas deferens were stimulated transmurally in vitro by passing square pulses between two platinum electrodes. The ultrastructural appearance of the adrenergic nerve terminals was compared to samples fixed immediately after 30 min of stimulation and in samples allowed to recover for 2 h before fixation. The contralateral vasa deferentia served as controls, and these were incubated in Krebs solution for the same period as stimulated muscles. For each of four experiments, the mean number of large and small dense-core vesicles per square micrometer was calculated, as were the mean area and perimeter of the axon varicosities in each group. It was found that the number of small vesicles per square micrometer decreased by 60% during the stimulation period, but returned almost to control levels 2 h later. Large vesicles did not change in number during the stimulation or recovery periods. The proportion of vesicles containing cores was also determined for each group and found to decline just after stimulation in the small vesicle population, but to remain constant in the large vesicle population. The core depletion was partly reversed after 2 h. The vesicle recovery process was studied by use of the extracellular tracer horseradish peroxidase (HRP). When HRP was present in the extracellular space during stimulation, large numbers of vesicles contained the marker after recovery from stimulation. Thus, it is proposed that adrenergic axon varicosities recycle vesicle membrane through the plasma membrane in a manner similar to that already described for cholinergic nerve terminals.

scholarly journals Post-receptor pathway of the ATP-induced relaxation in smooth muscle of the mouse vas deferens

1993 ◽  
Vol 110 (1) ◽  
pp. 326-330 ◽  
Author(s):  
Ph. Gailly ◽  
B. Boland ◽  
C. Paques ◽  
B. Himpens ◽  
R. Casteels ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vas Deferens ◽  
Mouse Vas Deferens
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