Algebraic Criteria for Qualitative Analysis of Nonlinear Dynamics in Biochemistry

Author(s):  
Kiriakos Kiriakidis ◽  
George Nakos

Aggregate modeling can approximate the convex hull of local matrices to nonlinear dynamics for any given accuracy. The authors use aggregate models to extend sufficient conditions for asymptotic stability of linear differential inclusions to nonlinear dynamics. An example illustrates the applicability of the proposed criteria to the analysis of nonlinear biochemical reaction chains.

Filomat ◽  
2018 ◽  
Vol 32 (7) ◽  
pp. 2367-2382
Author(s):  
Elimhan Mahmudov

In the paper minimization of a Lagrange type cost functional over the feasible set of solutions of higher order differential inclusions with endpoint constraints is studied. Our aim is to derive sufficient conditions of optimality for m th-order convex and non-convex differential inclusions. The sufficient conditions of optimality containing the Euler-Lagrange and Hamiltonian type inclusions as a result of endpoint constraints are accompanied by so-called ?endpoint? conditions. Here the basic apparatus of locally adjoint mappings is suggested. An application from the calculus of variations is presented and the corresponding Euler-Poisson equation is derived. Moreover, some higher order linear optimal control problems with quadratic cost functional are considered and the corresponding Weierstrass-Pontryagin maximum principle is constructed. Also at the end of the paper some characteristic features of the obtained result are illustrated by example with second order linear differential inclusions.


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