scholarly journals Elastic scattering spectroscopy for early detection of breast cancer: partially supervised Bayesian image classification of scanned sentinel lymph nodes

2018 ◽  
Vol 23 (08) ◽  
pp. 1
Keyword(s):  
Breast Cancer ◽  
Elastic Scattering ◽  
Early Detection ◽  
Lymph Nodes ◽  
Image Classification ◽  
Sentinel Lymph Nodes ◽  
Elastic Scattering Spectroscopy

Elastic Scattering Spectroscopy scanning of Sentinel Lymph Nodes for intraoperative diagnosis of breast cancer metastases

2008 ◽  
Author(s):  
Martin Austwick ◽  
Santosh Somasundaram ◽  
Wayne Chicken ◽  
Benjamin Clark ◽  
Charles A Mosse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Elastic Scattering ◽  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Intraoperative Diagnosis ◽  
Breast Cancer Metastases ◽  
Elastic Scattering Spectroscopy ◽  
Cancer Metastases

scholarly journals Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanfeng Dai ◽  
Xiang Yu ◽  
Jianshuang Wei ◽  
Fanxin Zeng ◽  
Yiran Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Scavenger Receptor ◽  
Intradermal Injection ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Surgery ◽  
Photoacoustic Microscopy ◽  
Dual Targeting ◽  
Scavenger Receptor Class ◽  
Distinct Distribution

Abstract Detection of sentinel lymph nodes (SLNs) is critical to guide the treatment of breast cancer. However, distinguishing metastatic SLNs from normal and inflamed lymph nodes (LNs) during surgical resection remains a challenge. Here, we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle (5K-HA-HPPS) loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer. The small sized (~40 nm) self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal injection. Compared with normal popliteal LNs (N-LN), there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs (T-MLN) and inflamed LNs (Inf-LN), respectively, 6 h after nanoparticle inoculation. More importantly, photoacoustic microscopy (PAM) of 5K-HA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and Inf-LN. Signals were mainly distributed at the centre of T-MLN but at the periphery of N-LN and Inf-LN. The ratio of PA intensity (R) at the centre of the LNs compared with that at the periphery was 5.93 ± 0.75 for T-MLNs of the 5K-HA-HPPS group, which was much higher than that for the Inf-LNs (R = 0.2 ± 0.07) and N-LNs (R = 0.45 ± 0.09). These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs, thus guiding the removal of SLNs during breast cancer surgery.

Contrast-enhanced ultrasound biopsy of sentinel lymph nodes in patients with breast cancer undergoing neo-adjuvant chemotherapy

2016 ◽  
Vol 42 (5) ◽  
pp. S57
Author(s):  
Sarah Horn ◽  
Jenny Weeks ◽  
Pippa Mills ◽  
David Fish ◽  
Karina Cox
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Neo Adjuvant Chemotherapy
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