By experimental method, the optimum parameters for offset ink were investigated under standard printing conditions. Firstly, the relationship between solid ink density and print contrast was established, and the optimum values of solid ink densities and print contrasts were calculated. Then, perfect tone reproduction was achieved by dot gain compensation, in which the calibration curves were obtained by the target curves and the initial tone value increase(TVI) curves based on optimum SIDs. The results showed that this method of determining the optimum parameters for offset inks were practicable and reliable, it can be used to research the printability of inks and papers, optimize printing process, improve printing quality, and provide method of standardization of process control for printing institutions.