Application of label-free SERS and EC-SERS for detection of traces of drugs in biological fluids.

Author(s):  
Martynas Velička ◽  
Sonata Adomavičiūtė ◽  
Edvinas Zacharovas ◽  
Valdas Šablinskas
Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4600 ◽  
Author(s):  
Ekaterina Khristunova ◽  
Elena Dorozhko ◽  
Elena Korotkova ◽  
Bohumil Kratochvil ◽  
Vlastimil Vyskocil ◽  
...  

A highly effective way to improve prognosis of viral infectious diseases and to determine the outcome of infection is early, fast, simple, and efficient diagnosis of viral pathogens in biological fluids. Among a wide range of viral pathogens, Flaviviruses attract a special attention. Flavivirus genus includes more than 70 viruses, the most familiar being dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV). Haemorrhagic and encephalitis diseases are the most common severe consequences of flaviviral infection. Currently, increasing attention is being paid to the development of electrochemical immunological methods for the determination of Flaviviruses. This review critically compares and evaluates recent research progress in electrochemical biosensing of DENV, ZIKV, and JEV without labelling. Specific attention is paid to comparison of detection strategies, electrode materials, and analytical characteristics. The potential of so far developed biosensors is discussed together with an outlook for further development in this field.


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