Automatic detection of ellipsoid zone loss due to Hydroxychloroquine retinal toxicity from SD-OCT imaging

2021 ◽  
Author(s):  
Tharindu S. De Silva ◽  
Gopal Jayakar ◽  
Peyton Grisso ◽  
Emily Y. Chew ◽  
Nathan Hotaling ◽  
...  
Keyword(s):  
Automatic Detection ◽  
Retinal Toxicity ◽  
Ellipsoid Zone ◽  
Oct Imaging ◽  
Sd Oct

scholarly journals External limiting membrane: retinal structural barrier in diabetic macular edema

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sandeep Saxena ◽  
Levent Akduman ◽  
Carsten H. Meyer
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Barrier Effect ◽  
External Limiting Membrane ◽  
Ellipsoid Zone ◽  
Structural Barrier ◽  
Sd Oct

AbstractAdvances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.

scholarly journals Comparison of macular choroidal thickness in patients with pseudoexfoliation syndrome to normal control subjects with enhanced depth SD-OCT imaging

2017 ◽  
Vol 29 (4) ◽  
pp. 258-263 ◽  
Author(s):  
Sasan Moghimi ◽  
Mehdi Mazloumi ◽  
Mohammad Karim Johari ◽  
Masoud Aghsaie Fard ◽  
Rebecca Chen ◽  
...  
Keyword(s):  
Normal Control ◽  
Choroidal Thickness ◽  
Pseudoexfoliation Syndrome ◽  
Control Subjects ◽  
Oct Imaging ◽  
Sd Oct

SD-OCT Imaging of Idiopathic Macular Holes With Spontaneous Closure

2012 ◽  
Author(s):  
Andrea Scupola ◽  
Alessandra C. Tiberti ◽  
Paola Sasso ◽  
Alessandra Mastrocola ◽  
Antonio Berarducci ◽  
...  
Keyword(s):  
Spontaneous Closure ◽  
Macular Holes ◽  
Idiopathic Macular Holes ◽  
Oct Imaging ◽  
Sd Oct

Optical Coherence Tomographic Features and Visual Prognosis after Treatment for Idiopathic Choroidal Neovascularization

2015 ◽  
Vol 234 (2) ◽  
pp. 67-72
Author(s):  
Xu-Sheng Cao ◽  
Xiao-Yan Peng ◽  
Qi-Sheng You ◽  
Yong-Peng Zhang ◽  
Jost B. Jonas
Keyword(s):  
Visual Acuity ◽  
Choroidal Neovascularization ◽  
Univariate Analysis ◽  
Final Visual Acuity ◽  
Lower Amount ◽  
Optical Coherence ◽  
Intravitreal Ranibizumab ◽  
Visual Prognosis ◽  
Ellipsoid Zone ◽  
Sd Oct

Background: The aim of this study was to determine whether pretreatment spectral-domain optical coherence tomographic (SD-OCT) features are associated with visual prognosis after treatment for idiopathic subfoveal choroidal neovascularization (ISCNV) with intravitreal ranibizumab. Methods: We retrospectively evaluated SD-OCT images of eyes with ISCNV undergoing treatment with intravitreal ranibizumab with a mean follow-up of 7 months. Results: This study included 22 patients (22 eyes) with a mean age of 32.7 ± 8.1 years. In univariate analysis, better final visual acuity expressed in logMAR units was significantly associated with a lower amount of pretreatment ellipsoid zone defects (p = 0.03; standardized correlation coefficient β = 0.46) and a lower amount of pretreatment external limiting membrane (ELM) damage (p = 0.007; β = 0.56). All other SD-OCT parameters were not significantly associated with final visual acuity. A higher improvement in visual acuity was marginally significantly associated with larger pretreatment ellipsoid zone defects (p = 0.049; β = -0.43). Conclusions: The integrity of the outer retinal layers at baseline, in particular of the ELM, is of importance in predicting the final visual outcome in patients undergoing intravitreal medical therapy for ISCNV.

scholarly journals Classification of healthy and diseased retina using SD-OCT imaging and Random Forest algorithm

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0198281 ◽  
Author(s):  
Md Akter Hussain ◽  
Alauddin Bhuiyan ◽  
Chi D. Luu ◽  
R. Theodore Smith ◽  
Robyn H. Guymer ◽  
...  
Keyword(s):  
Random Forest ◽  
Random Forest Algorithm ◽  
Oct Imaging ◽  
Sd Oct

Quantitative SD-OCT Imaging Biomarkers as Indicators of Age-Related Macular Degeneration Progression

2014 ◽  
Vol 55 (11) ◽  
pp. 7093 ◽  
Author(s):  
Luis de Sisternes ◽  
Noah Simon ◽  
Robert Tibshirani ◽  
Theodore Leng ◽  
Daniel L. Rubin
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Imaging Biomarkers ◽  
Age Related ◽  
Oct Imaging ◽  
Sd Oct

SEVERE ACUTE VISION LOSS, DYSCHROMATOPSIA, AND CHANGES IN THE ELLIPSOID ZONE ON SD-OCT ASSOCIATED WITH INTRAVITREAL OCRIPLASMIN INJECTION

2015 ◽  
Vol 9 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Carlos Quezada Ruiz ◽  
Dante J. Pieramici ◽  
Maʼan Nasir ◽  
Melvin Rabena ◽  
Robert L. Avery
Keyword(s):  
Vision Loss ◽  
Ellipsoid Zone ◽  
Sd Oct

scholarly journals Virtual-OCT: A simulated optical coherence tomography instrument

2014 ◽  
Vol 07 (05) ◽  
pp. 1450030 ◽  
Author(s):  
Ning Liu ◽  
Cuixia Dai ◽  
Yuanhe Tang ◽  
Peng Xi
Keyword(s):  
Optical Coherence Tomography ◽  
Dynamic Range ◽  
Partial Coherence ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Algorithm Optimization ◽  
Virtual Instrumentation ◽  
Parameter Evaluation ◽  
Oct Imaging ◽  
Sd Oct

We report the virtual instrumentation of both time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT) systems. With a virtual partial coherence source from either a simulated or measured spectrum, the OCT signals of both A-scan and B-scan were demonstrated. The spectrometric detector's pixel number, dynamic range, noise, as well as spectral resolution can be simulated in the virtual spectral domain (SD-OCT). The virtual-OCT system provides an environment for parameter evaluation and algorithm optimization for experimental OCT instrumentation, and promotes the understanding of OCT imaging and signal post-processing processes.

scholarly journals Longitudinal observation of OCT imaging is a valuable tool to monitor primary vitreoretinal lymphoma treated with intravitreal injections of methotrexate

2020 ◽  
Author(s):  
Huiying Zhao ◽  
Xiaona Wang ◽  
Yu Mao ◽  
Xiaoyan Peng
Keyword(s):  
Pigment Epithelium ◽  
Subretinal Fluid ◽  
Intravitreal Injections ◽  
Induction Treatment ◽  
Outer Retina ◽  
Vitreoretinal Lymphoma ◽  
Longitudinal Observation ◽  
Subretinal Fibrosis ◽  
Oct Imaging ◽  
Sd Oct

Abstract Background: Developing objective and repeatable indicators to evaluate the efficacy of PVRL treatment is important. The quantification of vitreous cells is a traditional criterion; however slight changes are difficult to ascertain. Spectral domain optical coherence tomography (SD-OCT) is objective, repeatable, and easily explained. The purpose of this study is to provide a longitudinal observation of OCT in PVRL treated with intravitreal injections of methotrexate (MTX) and to evaluate the utility of OCT in monitoring responsiveness of PVRL to treatment. Methods: The medical records of patients with biopsy-positive PVRL attending our hospital between January 2016 and September 2017 who received intravitreal injections of MTX were included in this study. Pre- and post-treatment OCT images were reviewed independently by two researchers. Results: Of the 24 cases reviewed, 10 patients (18 eyes) were included. SD-OCT abnormalities at the initial visit included vitreous cells (18/18), OR (outer retina) fuzzy borders (12/18), PED (pigment epithelium detachments) (9/18), subretinal hyperreflective infiltration (3/18), intraretinal infiltration (8/18), and SRF (subretinal fluid) (4/18). Post induction treatment, SRF in cases with RD (retinal detachment) was absorbed, and subretinal fibrosis appeared. Other lesions were significantly reduced. Post consolidation treatment, OR fuzzy borders, PED and SRF disappeared in 2 eyes, intraretinal infiltration disappeared in 1 eye, and other abnormalities further improved. Additionally, retinal fibrosis was observed in 3 eyes. One month post maintenance treatment, all abnormalities observed at the first visit vanished. At the last visit, OCT showed subretinal fibrosis and in 3 eyes (16.7%), the disruption of outer retina in 9 eyes (50%) and thinning of the whole layer in 4 eyes (22.2%). Conclusions: Our observations reveal that characteristic OCT features in PVRL patients can reduce gradually and finally vanish with therapy. We propose that SD-OCT may be employed to monitor the responsiveness of PVRL to treatment, which may influence decision making in the management of this disease.

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