SEVERE ACUTE VISION LOSS, DYSCHROMATOPSIA, AND CHANGES IN THE ELLIPSOID ZONE ON SD-OCT ASSOCIATED WITH INTRAVITREAL OCRIPLASMIN INJECTION

2015 ◽  
Vol 9 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Carlos Quezada Ruiz ◽  
Dante J. Pieramici ◽  
Maʼan Nasir ◽  
Melvin Rabena ◽  
Robert L. Avery
Keyword(s):  
Vision Loss ◽  
Ellipsoid Zone ◽  
Sd Oct

scholarly journals External limiting membrane: retinal structural barrier in diabetic macular edema

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sandeep Saxena ◽  
Levent Akduman ◽  
Carsten H. Meyer
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Barrier Effect ◽  
External Limiting Membrane ◽  
Ellipsoid Zone ◽  
Structural Barrier ◽  
Sd Oct

AbstractAdvances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.

Optical Coherence Tomographic Features and Visual Prognosis after Treatment for Idiopathic Choroidal Neovascularization

2015 ◽  
Vol 234 (2) ◽  
pp. 67-72
Author(s):  
Xu-Sheng Cao ◽  
Xiao-Yan Peng ◽  
Qi-Sheng You ◽  
Yong-Peng Zhang ◽  
Jost B. Jonas
Keyword(s):  
Visual Acuity ◽  
Choroidal Neovascularization ◽  
Univariate Analysis ◽  
Final Visual Acuity ◽  
Lower Amount ◽  
Optical Coherence ◽  
Intravitreal Ranibizumab ◽  
Visual Prognosis ◽  
Ellipsoid Zone ◽  
Sd Oct

Background: The aim of this study was to determine whether pretreatment spectral-domain optical coherence tomographic (SD-OCT) features are associated with visual prognosis after treatment for idiopathic subfoveal choroidal neovascularization (ISCNV) with intravitreal ranibizumab. Methods: We retrospectively evaluated SD-OCT images of eyes with ISCNV undergoing treatment with intravitreal ranibizumab with a mean follow-up of 7 months. Results: This study included 22 patients (22 eyes) with a mean age of 32.7 ± 8.1 years. In univariate analysis, better final visual acuity expressed in logMAR units was significantly associated with a lower amount of pretreatment ellipsoid zone defects (p = 0.03; standardized correlation coefficient β = 0.46) and a lower amount of pretreatment external limiting membrane (ELM) damage (p = 0.007; β = 0.56). All other SD-OCT parameters were not significantly associated with final visual acuity. A higher improvement in visual acuity was marginally significantly associated with larger pretreatment ellipsoid zone defects (p = 0.049; β = -0.43). Conclusions: The integrity of the outer retinal layers at baseline, in particular of the ELM, is of importance in predicting the final visual outcome in patients undergoing intravitreal medical therapy for ISCNV.

A mutation in CRX causing pigmented paravenous retinochoroidal atrophy

2020 ◽  
pp. 112067212095759
Author(s):  
Jin Kyun Oh ◽  
Yan Nuzbrokh ◽  
Winston Lee ◽  
Jose Ronaldo Lima de Carvalho ◽  
Nan Kai Wong ◽  
...  
Keyword(s):  
Vision Loss ◽  
Retinal Dystrophy ◽  
Cone Dystrophy ◽  
Full Field ◽  
Inherited Retinal Dystrophy ◽  
History Of ◽  
Pigmented Paravenous Retinochoroidal Atrophy ◽  
Retinal Thinning ◽  
Bull's Eye ◽  
Sd Oct

Introduction: Mutations in the cone-rod homeobox ( CRX) gene, a known cause of inherited retinal dystrophy, are characterized by extensive phenotypic heterogeneity. We describe a novel presentation of rod-cone dystrophy (RCD) phenocopying pigmented paravenous retinochoroidal atrophy associated with a mutation in CRX. Case description: A 53-year-old man and his 48-year-old brother presented with a history of progressive vision loss and nyctalopia. Fundus examination revealed a bull’s eye lesion with chorioretinal atrophy and intraretinal pigment migration, while spectral-domain optical coherence tomography (SD-OCT) demonstrated retinal thinning with outer retinal atrophy. On short-wavelength autofluorescence (SW-AF) imaging, an atypical paravenous pattern of atrophy with a surrounding hyperautofluorescent border was observed. Full-field electroretinogram (ffERG) revealed a rod-cone pattern of dysfunction. A heterozygous pathogenic variant, c.119G>A:p.(Arg40Gln), in the CRX gene was identified in both brothers and segregated in their family. Conclusion: This case report broadens the currently known phenotypic presentations of CRX-associated retinopathy and suggests that mutations in CRX may be associated with pigmented paravenous retinochoroidal atrophy.

scholarly journals Spontaneous closure of degenerative lamellar macular hole with epiretinal membrane proliferation

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rony C. Preti ◽  
Leandro C. Zacharias ◽  
Leonardo P. Cunha ◽  
Mario L. R. Monteiro ◽  
David Sarraf
Keyword(s):  
Macular Hole ◽  
Epiretinal Membrane ◽  
Vision Loss ◽  
Surgical Intervention ◽  
Spontaneous Closure ◽  
Müller Cell ◽  
Lamellar Macular Hole ◽  
Cystic Fluid ◽  
Muller Cell ◽  
Sd Oct

Abstract Background To describe the spontaneous closure of a degenerative lamellar macular hole with epiretinal proliferation (LHEP) as documented with tracked spectral domain optical coherence tomography (SD-OCT). Case presentation A 54-years-old diabetic female patient presented with progressive vision loss in the left eye. SD-OCT illustrated LHEP associated with cystic fluid in the outer nuclear layer. Sequentially tracked SD-OCT showed progressive closure of the degenerative lamellar macular hole and resolution of the CME over almost 4 years, in the absence of any surgical intervention. Discussion/conclusion LHEP may represent a specialized form of degenerative epiretinal membrane associated with Muller cell activation. Spontaneous degenerative LMH closure may rarely occur with these lesion types, in the absence of surgical intervention, possibly due to Muller cell proliferation preceded by PVD.

scholarly journals The Change in Retinal Ellipsoid Zone Thickness in Patients with Reticular Macular Disease

2021 ◽  
Author(s):  
Yuyao Diao ◽  
Hua Hao ◽  
Lu Cheng ◽  
Varun Pattisapu ◽  
Hao Huang ◽  
...  
Keyword(s):  
Vision Loss ◽  
Photoreceptor Cells ◽  
Estimating Equation ◽  
Posterior Pole ◽  
Control Group ◽  
Macular Disease ◽  
The Mean ◽  
Medical University ◽  
Control Study ◽  
Sd Oct

Abstract Purpose: Compare the thickness of the retinal ellipsoidal zone in patients with Reticular Macular Disease (RMD) to a control population.Methods: This case-control study was conducted on patients diagnosed with RMD at the First Affiliated Hospital of Guangzhou Medical University from April 2018 to November 2018. We identified 25 cases who were diagnosed with RMD and 20 normal control eyes. Divide the posterior pole into five regions (superior, inferior, nasal, temporal, and subfoveal zones), and manually measure the five regions posterior ellipsoidal zone thickness, all the images were obtained by SD-OCT. Generalized estimating equation models were used to control for potential confounders and within-subject variation.Results: The mean ellipsoidal zone thickness in RMD patients five regions were all significantly lower than in the control group (all P<0.01). The mean ellipsoidal zone thickness value in men with RMD has a more significant change than females. Furthermore, the mean ellipsoidal zone thickness of reticular pseudodrusen (RPD) eyes with drusen were not significantly different from the pure RPD eyes (P=0.34). Conclusions: Our findings reveal that the mechanism of RMD occurs may be related to damage to the mitochondria of photoreceptor cells, which may be one of the mechanisms that RMD occurs. When the impairment degree of mitochondria reach to a certain level, may lead to further vision loss in RMD patients. Therefore, to protect the retinal ellipsoidal zone and its mitochdrial early is important to prevent further impairment of visual function and vision loss.

The Use of Optical Coherence Tomography for the Detection of Early Diabetic Retinopathy

2018 ◽  
Vol 235 (04) ◽  
pp. 377-384 ◽  
Author(s):  
Gabor Mark Somfai ◽  
Heinrich Gerding ◽  
Delia DeBuc
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Vision Loss ◽  
Optical Coherence ◽  
Recent Developments ◽  
Cholesterol Control ◽  
Available Technology ◽  
High Treatment ◽  
Sd Oct

AbstractDiabetic retinopathy (DR) is one of the leading causes of vision loss globally with a severe burden on all societies due to its high treatment and rehabilitation costs. The early diagnosis of DR may provide preventive steps (including retinal laser therapy and tight carbohydrate, blood pressure, and cholesterol control) that could in turn help to avoid progression of the pathology with the resultant vision loss. Optical coherence tomography (OCT) enables the in vivo structural imaging of the retina, providing both qualitative (structure) and quantitative (thickness) information. In the past decades, extensive OCT research has been done in the field of DR. In the present review, we are focusing on those that were aiming at detection of the earliest retinal changes before DR could be diagnosed funduscopically. The latest, widely available technology of spectral-domain (SD-)OCT comes with a fast and reliable retinal imaging, which, together with the most recent developments in image processing and artificial intelligence, holds the promise of developing a quick and efficient, state-of-the-art screening tool for DR.

scholarly journals Microvascular Capillary Plexus Findings of Commotio Retinae on Optical Coherence Tomography Angiography

2018 ◽  
Vol 9 (3) ◽  
pp. 473-478 ◽  
Author(s):  
Ahmad M. Mansour ◽  
Carol L. Shields
Keyword(s):  
Optical Coherence Tomography ◽  
Capillary Density ◽  
Foveal Avascular Zone ◽  
Tennis Ball ◽  
Optical Coherence ◽  
Ellipsoid Zone ◽  
Spectral Domain Oct ◽  
Capillary Plexus ◽  
Commotio Retinae ◽  
Sd Oct

Optical coherence tomography (OCT) and histopathology features of commotio retinae (CR) have been established, but alterations of the microvascular macular capillary plexus on OCT angiography (OCTA) has not been previously studied. We present a 46-year-old man who sustained a tennis ball injury to the right eye with visual acuity reduction to 20/30 and grey-white deep macular discoloration, suggestive of CR. Spectral-domain OCT (SD-OCT) showed increased reflectivity and thickness of the ellipsoid zone (junction of photoreceptor inner and outer segments). OCTA revealed no apparent microvascular alterations (right versus left eye) in the foveal avascular zone superficial (0.42 vs. 0.43 mm2) and deep (0.45 vs. 0.44 mm2), superficial foveal capillary density (34.1 vs. 32.6%), and superficial parafoveal capillary density (55.2 vs. 52.2%). Deep macular capillary plexus and choriocapillaris were qualitatively comparable between the two eyes. At 2 months’ follow-up, SD-OCT had normalized. CR is characterized by disruption of the ellipsoid zone without detectable alteration of the capillary plexuses.

scholarly journals External limiting membrane and ellipsoid zone structural integrity in diabetic macular edema

2021 ◽  
pp. 112067212110261
Author(s):  
Sandeep Saxena ◽  
Carsten H Meyer ◽  
Levent Akduman
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Structural Integrity ◽  
External Limiting Membrane ◽  
Ellipsoid Zone ◽  
Anti Vegf ◽  
Central Subfield Thickness ◽  
Structural Barrier ◽  
Sd Oct

The external limiting membrane (ELM) and ellipsoid zone (EZ) can be observed exquisitely by SD-OCT. In diabetic macular edema (DME), dysfunction of mitochondria, represented by the EZ in the foveal photoreceptors results in reduced visual acuity (VA). An increase in VEGF was found to correlate with increased severity of DR, increased central subfield thickness (CST), and sequential disruption of ELM and EZ. The mechanism of ELM and EZ restoration after anti-VEGF therapy in DME has been discovered. The ELM restores first followed by EZ restoration. Thus, authors have discovered and established ELM as a novel retinal structural barrier.

scholarly journals Correlation between Visual Acuity, Inner Segment/Outer Segment Junction, and Cone Outer Segment Tips Line Integrity in Uveitic Macular Edema

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Paolo Tortorella ◽  
Enzo D’Ambrosio ◽  
Ludovico Iannetti ◽  
Federica De Marco ◽  
Maurizio La Cava
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Outer Segment ◽  
Poor Vision ◽  
Ellipsoid Zone ◽  
Logistic Analysis ◽  
Uveitic Macular Edema ◽  
Interdigitation Zone ◽  
Spectralis Oct ◽  
Sd Oct

Purpose. To investigate the correlation between best-corrected visual acuity (BCVA), the foveal inner segment/outer segment (IS/OS) junction or ellipsoid portion of inner segment (EPIS/ellipsoid zone), and the cone outer segment tips (COST) line or interdigitation zone integrity in eyes with uveitic macular edema (ME).Method. A retrospective observational study involving all patients from January 2012 to December 2013 with uveitic ME was performed. All patients underwent BCVA using Snellen charts spectral-domain optical coherence tomography (SD-OCT) examination using Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany).Results. Fifty-two eyes from 45 patients were included in this study. Multivariate analysis showed a negative correlation between BCVA and the central retinal subfield thickness (CST), the cystoid pattern of edema, and the interdigitation zone interruption. Univariate logistic analysis showed a strong correlation between the ellipsoid zone and the interdigitation zone integrity.Conclusions. The ellipsoid zone defect, the interdigitation zone interruption, and the CST are correlated with poor vision. Visual acuity is also strongly affected by the cystoid pattern. The interdigitation zone integrity appears to be the most important factor in the visual prognosis of uveitic ME.

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