scholarly journals Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 181
Author(s):  
Loredana G. Marcu ◽  
Eva Bezak ◽  
Dylan D. Peukert ◽  
Puthenparampil Wilson
Keyword(s):  
Dose Rate ◽  
High Dose Rate ◽  
Current Status ◽  
Therapeutic Window ◽  
High Dose ◽  
Linear Accelerators ◽  
Radiation Delivery ◽  
Tissue Sparing

FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy. Thus far, most in vitro and in vivo results show a real potential of FLASH to offer superior normal tissue sparing compared to conventionally delivered radiation. While there are several postulations behind the differential behaviour among normal and cancer cells under FLASH, the full spectra of radiobiological mechanisms are yet to be clarified. Currently the number of devices delivering FLASH dose rate is few and is mainly limited to experimental and modified linear accelerators. Nevertheless, FLASH research is increasing with new developments in all the main areas: radiobiology, technology and clinical research. This paper presents the current status of FLASH radiotherapy with the aforementioned aspects in mind, but also to highlight the existing challenges and future prospects to overcome them.

PO-1632 3D-Printed template to perform in vivo dosimetry in breast high dose rate brachytherapy treatments

2021 ◽  
Vol 161 ◽  
pp. S1353-S1354
Author(s):  
M. Gutiérrez Ruiz ◽  
R. Astudillo Olalla ◽  
A.L. Rivero ◽  
P. érez ◽  
J.T. Anchuelo Latorre ◽  
...  
Keyword(s):  
Dose Rate ◽  
High Dose Rate ◽  
In Vivo Dosimetry ◽  
High Dose ◽  
High Dose Rate Brachytherapy ◽  
3D Printed

Perioperative high-dose-rate brachytherapy in soft tissue sarcomas of the extremity and superficial trunk in adults: Initial results of a pilot study

Brachytherapy ◽  
2005 ◽  
Vol 4 (4) ◽  
pp. 264-270 ◽  
Author(s):  
Rafael Martínez-Monge ◽  
Mikel San Julián ◽  
Santiago Amillo ◽  
Mauricio Cambeiro ◽  
Leire Arbea ◽  
...  
Keyword(s):  
Pilot Study ◽  
Soft Tissue ◽  
Dose Rate ◽  
Soft Tissue Sarcomas ◽  
High Dose Rate ◽  
High Dose ◽  
High Dose Rate Brachytherapy ◽  
Initial Results

Characterization of microMOSFET detectors for in vivo dosimetry in high‐dose‐rate brachytherapy with 192 Ir

2020 ◽  
Vol 47 (5) ◽  
pp. 2242-2253 ◽  
Author(s):  
Samuel Ruiz‐Arrebola ◽  
Rosa Fabregat‐Borrás ◽  
Eduardo Rodríguez ◽  
Manuel Fernández‐Montes ◽  
Mercedes Pérez‐Macho ◽  
...  
Keyword(s):  
Dose Rate ◽  
High Dose Rate ◽  
In Vivo Dosimetry ◽  
High Dose ◽  
High Dose Rate Brachytherapy
Sign in / Sign up

Export Citation Format

Share Document