proton irradiation
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Author(s):  
Giuseppe Dilillo ◽  
Nicola Zampa ◽  
Riccardo Campana ◽  
Fabio Fuschino ◽  
Giovanni Pauletta ◽  
...  

2022 ◽  
pp. 1-5
Author(s):  
Morten B. Jensen ◽  
Lia B. Valdetaro ◽  
Peter Balling ◽  
Peter S. Skyt ◽  
Jørgen B. B. Petersen ◽  
...  

2022 ◽  
Vol 12 (2) ◽  
pp. 823
Author(s):  
Md. Rafiqul Islam ◽  
Mehrdad Shahmohammadi Beni ◽  
Shigeki Ito ◽  
Shinichi Gotoh ◽  
Taiga Yamaya ◽  
...  

Proton range monitoring and verification is important to enhance the effectiveness of treatment by ensuring that the correct dose is delivered to the correct location. Upon proton irradiation, different positron emitting radioisotopes are produced by the inelastic nuclear interactions of protons with the target elements. Recently, it was reported that the 16O(p,2p2n)13N reaction has a relatively low threshold energy, and it could be potentially used for proton range verification. In the present work, we have proposed an analysis scheme (i.e., algorithm) for the extraction and three-dimensional visualization of positron emitting radioisotopes. The proposed step-by-step analysis scheme was tested using our own experimentally obtained dynamic data from a positron emission mammography (PEM) system (our developed PEMGRAPH system). The experimental irradiation was performed using an azimuthally varying field (AVF) cyclotron with a 80 MeV monoenergetic pencil-like beam. The 3D visualization showed promising results for proton-induced radioisotope distribution. The proposed scheme and developed tools would be useful for the extraction and 3D visualization of positron emitting radioisotopes and in turn for proton range monitoring and verification.


2022 ◽  
Vol 11 ◽  
Author(s):  
Dandan Wang ◽  
Ruifeng Liu ◽  
Qiuning Zhang ◽  
Hongtao Luo ◽  
Junru Chen ◽  
...  

PurposeGiven the higher precision accompanied by optimized sparing of normal tissue, charged particle therapy was thought of as a promising treatment for pancreatic cancer. However, systematic preclinical studies were scarce. We aimed to investigate the radiobiological effects of charged particle irradiation on pancreatic cancer cell lines.MethodsA systematic literature search was performed in EMBASE (OVID), Medline (OVID), and Web of Science databases. Included studies were in vitro English publications that reported the radiobiological effects of charged particle irradiation on pancreatic cancer cells.ResultsThirteen carbon ion irradiation and seven proton irradiation in vitro studies were included finally. Relative biological effectiveness (RBE) values of carbon ion irradiation and proton irradiation in different human pancreatic cancer cell lines ranged from 1.29 to 4.5, and 0.6 to 2.1, respectively. The mean of the surviving fraction of 2 Gy (SF2) of carbon ion, proton, and photon irradiation was 0.18 ± 0.11, 0.48 ± 0.11, and 0.57 ± 0.13, respectively. Carbon ion irradiation induced more G2/M arrest and a longer-lasting expression of γH2AX than photon irradiation. Combination therapies enhanced the therapeutic effects of pancreatic cell lines with a mean standard enhancement ratio (SER) of 1.66 ± 0.63 for carbon ion irradiation, 1.55 ± 0.27 for proton irradiation, and 1.52 ± 0.30 for photon irradiation. Carbon ion irradiation was more effective in suppressing the migration and invasion than photon irradiation, except for the PANC-1 cells.ConclusionsCurrent in vitro evidence demonstrates that, compared with photon irradiation, carbon ion irradiation offers superior radiobiological effects in the treatment of pancreatic cancer. Mechanistically, high-LET irradiation may induce complex DNA damage and ultimately promote genomic instability and cell death. Both carbon ion irradiation and proton irradiation confer similar sensitization effects in comparison with photon irradiation when combined with chemotherapy or targeted therapy.


2022 ◽  
pp. 107427
Author(s):  
Yang Lei ◽  
Liping Zhang ◽  
Liang Zhou ◽  
Jiaxin Yu ◽  
Gai Zhao ◽  
...  

2022 ◽  
Vol 2155 (1) ◽  
pp. 012004
Author(s):  
T Aldabergenova ◽  
M Baigonov ◽  
L Dikova ◽  
S Kislitsin

Abstract This paper presents the research results the surface structure evolution of high-purity tungsten after irradiation with 350 keV protons and subsequent annealing in the temperature range 600 – 1000 °C. Irradiation to a fluence of 5×1017 cm‒2 leads to blisters formation on the irradiated surface. Successive two-hour annealing results in the evolution of the distribution of blisters - the total number of blisters decreases while the fraction of larger blisters increases. At an annealing temperature of 1000C, the blisters dissolve. Do not observed the blisters disclosure and surface flaking both after proton irradiation and subsequent annealing in temperature range 600 – 1000 °C.


2021 ◽  
Vol 6 (48) ◽  
pp. 35-35
Author(s):  
Elizaveta Kazakova ◽  
Marina Podobed ◽  
Alexander Prazyan ◽  
Daria Babina ◽  
Ekaterina Shesterikova ◽  
...  

A number of morphophysiological parameters of the candidate crop Lactuca sativa L. for growing in space after influence of the combined action of proton irradiation and clinostating were assessed. It was found that the effect of simulated space conditions reduces the surface area of leaf blades, the mass of roots and shoots of lettuce plants, was not change the number of true leaves. After 20 days of cultivation of L. sativa after irradiation and clinostating, the values of the parameters of the length of shoots, roots, and chlorophyll fluorescence were at the level of control plants. The results obtained contribute to the development of space crop production. Key words: GROWING PLANTS IN SPACE, SALAD CROPS, SOWED LETTUCE, IRRADIATION, PROTONS, STRESS, CLINOSTAT


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