Texture analysis of clinical radiographs using radon transform on a local scale for differentiation between post-menopausal women with and without hip fracture

2011 ◽  
Author(s):  
Holger F. Boehm ◽  
Markus Körner ◽  
Bernhard Baumert ◽  
Ulrich Linsenmaier ◽  
Maximilian Reiser
Keyword(s):  
Hip Fracture ◽  
Texture Analysis ◽  
Radon Transform ◽  
Local Scale ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals A Preliminary Evaluation of the Ability of Keratotic Tissue to Act as a Prognostic Indicator of Hip Fracture Risk

2018 ◽  
Vol 11 ◽  
pp. 117954411775405 ◽  
Author(s):  
J Renwick Beattie ◽  
Diane Feskanich ◽  
M Clare Caraher ◽  
Mark R Towler
Keyword(s):  
Raman Spectroscopy ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Spectroscopic Analysis ◽  
Prognostic Indicator ◽  
Health Study ◽  
Preliminary Evaluation ◽  
Predictive Values ◽  
Menopausal Women ◽  
Post Menopausal

Studies have shown that Raman spectroscopic analysis of fingernail clippings can help differentiate between post-menopausal women who have and who have not suffered a fracture. However, all studies to date have been retrospective in nature, comparing the proteins in nails sourced from women, post-fracture. The objective of this study was to investigate the potential of a prospective test for hip fracture based on spectroscopic analysis of nail tissue. Archived toenail samples from post-menopausal women aged 50 to 63 years in the Nurses’ Health Study were obtained and analysed by Raman spectroscopy. Nails were matched case-controls sourced from 161 women; 82 who underwent a hip fracture up to 20 years after nail collection and 81 age-matched controls. A number of clinical risk factors (CRFs) from the Fracture Risk Assessment (FRAX) tool had been assessed at toenail collection. Using 80% of the spectra, models were developed for increasing time periods between nail collection and fracture. Scores were calculated from these models for the other 20% of the sample and the ability of the score to predict hip fracture was tested in model with and without the CRFs by comparing the odds ratios (ORs) per 1 SD increase in standardised predictive values. The Raman score successfully distinguished between hip fracture cases and controls. With only the score as a predictor, a statistically significant OR of 2.2 (95% confidence interval [CI]: 1.5-3.1) was found for hip fracture for up to 20 years after collection. The OR increased to 3.8 (2.6-5.4) when the CRFs were added to the model. For fractures limited to 13 years after collection, the OR was 6.3 (3.0-13.1) for the score alone. The test based on Raman spectroscopy has potential for identifying individuals who may suffer hip fractures several years in advance. Higher powered studies are required to evaluate the predictive capability of this test.

scholarly journals Prevalence of Osteoporosis and Risk of Developing Fragility Fracture in Post-Menopausal Women

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Muhammad Hafiz Bin Hamzah ◽  
Aminudin Che Ahmad
Keyword(s):  
Hip Fracture ◽  
Fragility Fracture ◽  
Assessment Tool ◽  
Health Concern ◽  
Bone Mass Density ◽  
Average Risk ◽  
Average Percentage ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Prevalence Of Osteoporosis

Introduction: Osteoporosis and fragility fracture pose major health concern and cause significant financial burdens in healthcare system. The objectives of this study were to determine the prevalence of osteoporosis among post-menopausal women and to predict the risk of having the major osteoporotic and hip fracture in 10 years using the WHO Fracture Risk Assessment Tool. Materials and Methods: This was a cross-sectional study spanning over a two-year period (from June 2015 to June 2017) investigating post-menopausal women who did their Bone Mass Density (BMD) test at Hospital Melaka. Collected BMD data and parameters were used for analysif of the prevalence of osteoporosis among the study population and FRAX calculation was used to predict the average risk of fragility fracture in 10 years. Statistical analysis was done using SPSS statistical package. Results: Prevalence of osteoporosis among 388 post-menopausal women age 45 to 90 years old was 29.9%. More than half of patients had osteoporosis were Chinese (51%) followed by Malay (43%), Indian (5%) and others (1%). The 10 years average percentage of developing major osteoporosis was 10.81 ± 9.55 %, while the average percentage of developing hip fracture was 4.20 ± 6.53. Conclusion: Prevalence of the post-menopausal women who were osteoporotic was about 30% which is comparable to other countries (Japan, Egypt, Australia, Mexico, Argentina and India). The 10 years average percentage of developing major osteoporosis and hip fracture in our study is quite high, approximately around 20% and 10%, respectively.

scholarly journals MOF/Hip fracture ratio in a Belgian cohort of post-menopausal women (FRISBEE): Potential impact on the FRAX® score

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100809
Author(s):  
Aude Mugisha ◽  
Pierre Bergmann ◽  
Virginie Kinnard ◽  
Laura Iconaru ◽  
Felicia Baleanu ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Menopausal Women ◽  
Potential Impact ◽  
Post Menopausal

scholarly journals Preference for wine is associated with lower hip fracture incidence in post-menopausal women

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Jessica T Kubo ◽  
Marcia L Stefanick ◽  
John Robbins ◽  
Jean Wactawski-Wende ◽  
Mark R Cullen ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Fracture Incidence ◽  
Hip Fracture Incidence ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals POS1116 ENHANCING OSTEOPOROSIS MANAGEMENT: THE CONTRIBUTION OF FRAX® AND VFA IN TUNISIAN WOMEN

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 837.3-838
Author(s):  
C. Daldoul ◽  
N. El Amri ◽  
S. Laataoui ◽  
K. Baccouche ◽  
H. Zegaloui ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Fracture Risk ◽  
Osteoporotic Fractures ◽  
Interquartile Range ◽  
Therapeutic Decision ◽  
Major Osteoporotic Fractures ◽  
Menopausal Women ◽  
The Mean ◽  
The Difference ◽  
Post Menopausal

Background:The FRAX® is a tool proposed by the World Health Organization (WHO) to calculate 10-year fracture risk of hip fracture and major osteoporotic fractures. The utility of this tool is to help treatment decision when it is litigious. Previous low trauma fracture represent a factor in FRAX® calculation. However, asymptomatic osteoporotic vertebral fractures (VF) identified on X-rays or Vertebral Fracture Assessment (VFA) scans are rarely included. To the best of our knowledge, there was no previous evaluation of fracture risk in Tunisian women.Objectives:To compare hip fracture risk and major osteoporotic fractures risk using the FRAX® tool, without and with the consideration of asymptomatic VF on VFA. To evaluate the impact of FRAX® calculation and asymptomatic VF identified on VFA on osteoporosis management.Methods:We conducted a cross-sectional study over a period of 5 months at the rheumatology department. The study included post-menopausal women without a previous diagnosis of VF referred for BMD (Bone mineral density) measurement. Each participant had a BMD assessment and a VFA scan to detect VF. The FRAX® was calculated using femoral neck BMD initially without then with consideration of VF. The change of therapeutic decision was assessed after taking into consideration FRAX® and the VFA results.Results:The study included 210 post-menopausal women with a mean age of 61.5±8.5 years. The mean BMI was 31.04±5.52 kg/m2. One women was a current smoker and alcohol intake was not found in our sample. Thirty-seven percent of our participants had at least one fragility fracture. A severe fragility fracture was recorded in 10.5% and a previous hip fracture was reported in 5.24%. An early menopause was found in 19.5% of our women. Twenty percent of our population were receiving corticosteroids and 8.2% of our population had rheumatoid arthritis. The mean vertebral and total hip BMD was 0.955±0.165 g/cm2 and 0.850±0.135 g/cm2 respectively. Osteoporosis and low BMD were found in respectively 50% and 34.28%. The median probability of major osteoporotic fracture for our population was 1.5% with an interquartile range from 0.9 to 2.5% without using VFA data and 1.65% with an interquartile range from 1 to 2.6% while taking into consideration VFA results and the difference was statistically significant (p<0.0001). The median probability of hip fracture for our population was 0.4% with an interquartile range from 0.1 to 0.9% without using VFA data and 0.4% with an interquartile range from 0.1 to 1% while taking into consideration VFA results and the difference was statistically significant (p<0.0001). In all patients, the FRAX® was under the threshold intervention even after including the asymptomatic VF and it did not change the therapeutic decision. The presence of asymptomatic VF on VFA changed the therapeutic decision in 15% and indicated an anti-osteoporosis drug therapy.Conclusion:VFA scanning helped in the therapeutic decision in 15% of our population. In this evaluation, we showed that a comprehensive fracture risk pathway incorporating VFA has enhanced diagnosis of vertebral fractures and improved targeting of treatment better than FRAX® tool.Disclosure of Interests:None declared.

Sign in / Sign up

Export Citation Format

Share Document