SU-D-220-01: Hybrid X-Ray/Ultrasound Imaging Approach for Patient Positioning and Real-Time Tracking in IGRT

2011 ◽  
Vol 38 (6Part3) ◽  
pp. 3389-3390 ◽  
Author(s):  
J Schlosser ◽  
K Salisbury ◽  
L Xing ◽  
D Hristov
2020 ◽  
Vol 7 (5) ◽  
pp. 054702
Author(s):  
L. Henry ◽  
M. R. Panman ◽  
L. Isaksson ◽  
E. Claesson ◽  
I. Kosheleva ◽  
...  

1996 ◽  
Author(s):  
Primo Zingaretti ◽  
Guido Tascini ◽  
Paolo Puliti ◽  
Silvia Zanoli

2020 ◽  
Vol 6 (12) ◽  
pp. eaaz0981 ◽  
Author(s):  
Harsha Ravishankar ◽  
Martin Nors Pedersen ◽  
Mattias Eklund ◽  
Aljona Sitsel ◽  
Chenge Li ◽  
...  

Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) transporters regulate calcium signaling by active calcium ion reuptake to internal stores. Structural transitions associated with transport have been characterized by x-ray crystallography, but critical intermediates involved in the accessibility switch across the membrane are missing. We combined time-resolved x-ray solution scattering (TR-XSS) experiments and molecular dynamics (MD) simulations for real-time tracking of concerted SERCA reaction cycle dynamics in the native membrane. The equilibrium [Ca2]E1 state before laser activation differed in the domain arrangement compared with crystal structures, and following laser-induced release of caged ATP, a 1.5-ms intermediate was formed that showed closure of the cytoplasmic domains typical of E1 states with bound Ca2+ and ATP. A subsequent 13-ms transient state showed a previously unresolved actuator (A) domain arrangement that exposed the ADP-binding site after phosphorylation. Hence, the obtained TR-XSS models determine the relative timing of so-far elusive domain rearrangements in a native environment.


Biomaterials ◽  
2014 ◽  
Vol 35 (36) ◽  
pp. 9689-9697 ◽  
Author(s):  
Zhigao Yi ◽  
Wei Lu ◽  
Yaru Xu ◽  
Jing Yang ◽  
Li Deng ◽  
...  
Keyword(s):  
X Ray ◽  

Author(s):  
Aaron Sujar ◽  
Graham Kelly ◽  
Marcos García ◽  
Franck P. Vidal

Abstract Purpose Traditional undergraduate radiographer training mixes academic lectures and clinical practice. Our goal is to bridge the current disconnection between theory and practice in a safe environment, avoiding the risk of radiation for both practitioners and patients. To this end, this research proposes a new software to teach diagnostic radiography using real-time interactive X-ray simulation and patient positioning. Methods The proposed medical simulator is composed of three main modules. A fast and accurate character animation technique is in charge of simulating the patient positioning phase and adapts their internal anatomy accordingly. gVirtualXRay is an open-source X-ray simulation library and generates the corresponding radiographs in real time. Finally, the courseware allows going through all the diagnostic radiology steps from the patient positioning and the machine configuration to the final image enhancing. Results A face and content validation study has been conducted; 18 radiology professionals were recruited to evaluate our software using a questionnaire. The results show that our tool is realistic in many ways (72% of the participants agreed that the simulations are visually realistic), useful (67%) and suitable (78%) for teaching X-ray radiography. Conclusions The proposed tool allows simulating the most relevant steps of the projectional radiography procedure. The virtual patient posing system and X-ray simulation module execute at interactive rates. These features enable the lectures to show their students the results of good and bad practices in a classroom environment, avoiding radiation risk.


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