TU-A-WAB-08: Strong Evidence for Physiologic Correlation of 4D-CT Ventilation Imaging with Respiratory-Correlated Gallium 68 PET/CT in Humans

Abstract This study was designed to evaluate the accuracy of to detect pulmonary emboli (PE) the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n=6) and sham (n=6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. All cases were performed ventilation imaging first. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard.A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MAA PET/CT V/Q scans. Technegas/68Ga-MAA V/Q scans have good sensitivity, specificity and accuracy in the detection of PE in this animal model study.

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Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

10.21203/rs.3.rs-17621/v2 ◽

2020 ◽

Author(s):

Aziz Gültekin ◽

Mustafa Çağdaş Çayır ◽

Ayşe Uğur ◽

Ferda Bir ◽

Doğangün Yüksel

Keyword(s):

Ct Perfusion ◽

Rabbit Model ◽

Histopathological Analysis ◽

Model Study ◽

Ventilation Imaging ◽

Pet Ct ◽

Medicine Physician ◽

Animal Model Study ◽

Gallium 68 ◽

Sensitivity Specificity

Abstract This study was designed to evaluate the accuracy of to detect pulmonary emboli (PE) the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n=6) and sham (n=6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. All cases were performed ventilation imaging first. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard.A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MAA PET/CT V/Q scans. Technegas/68Ga-MAA V/Q scans have good sensitivity, specificity and accuracy in the detection of PE in this animal model study.

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Comparison of Fluorine(18)-fluorodeoxyglucose and Gallium(68)-citrate PET/CT in patients with tuberculosis

Nuklearmedizin ◽

10.1055/a-1000-6951 ◽

2019 ◽

Vol 58 (05) ◽

pp. 371-378

Author(s):

Alfred O. Ankrah ◽

Ismaheel O. Lawal ◽

Tebatso M.G. Boshomane ◽

Hans C. Klein ◽

Thomas Ebenhan ◽

...

Keyword(s):

Tracer Uptake ◽

Pet Ct ◽

The Mean ◽

18F Fdg ◽

Definition Of ◽

Gallium 68 ◽

Attending Physician ◽

Pet Scans ◽

The Brain

Abstract 18F-FDG and 68Ga-citrate PET/CT have both been shown to be useful in the management of tuberculosis (TB). We compared the abnormal PET findings of 18F-FDG- and 68Ga-citrate-PET/CT in patients with TB. Methods Patients with TB on anti-TB therapy were included. Patients had a set of PET scans consisting of both 18F-FDG and 68Ga-citrate. Abnormal lesions were identified, and the two sets of scans were compared. The scan findings were correlated to the clinical data as provided by the attending physician. Results 46 PET/CT scans were performed in 18 patients, 11 (61 %) were female, and the mean age was 35.7 ± 13.5 years. Five patients also had both studies for follow-up reasons during the use of anti-TB therapy. Thirteen patients were co-infected with HIV. 18F-FDG detected more lesions than 68Ga-citrate (261 vs. 166, p < 0.0001). 68Ga-citrate showed a better definition of intracerebral lesions due to the absence of tracer uptake in the brain. The mean SUVmax was higher for 18F-FDG compared to 68Ga-citrate (5.73 vs. 3.01, p < 0.0001). We found a significant correlation between the SUVmax of lesions that were determined by both tracers (r = 0.4968, p < 0.0001). Conclusion Preliminary data shows 18F-FDG-PET detects more abnormal lesions in TB compared to 68Ga-citrate. However, 68Ga-citrate has better lesion definition in the brain and is therefore especially useful when intracranial TB is suspected.

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