scholarly journals Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy

2016 ◽  
Vol 17 (5) ◽  
pp. 366-376 ◽  
Author(s):  
Xin Wang ◽  
Falk Poenisch ◽  
Narayan Sahoo ◽  
Ronald X. Zhu ◽  
MingFwu Lii ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Neutron Dose ◽  
Spot Scanning

Secondary neutron dose during proton therapy using spot scanning

2002 ◽  
Vol 53 (1) ◽  
pp. 244-251 ◽  
Author(s):  
Uwe Schneider ◽  
Stefano Agosteo ◽  
Eros Pedroni ◽  
Jürgen Besserer
Keyword(s):  
Proton Therapy ◽  
Neutron Dose ◽  
Secondary Neutron ◽  
Spot Scanning

scholarly journals A scanning dynamic collimator for spot-scanning proton minibeam production

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marios Sotiropoulos ◽  
Yolanda Prezado
Keyword(s):  
Monte Carlo ◽  
Radiation Therapy ◽  
Monte Carlo Simulations ◽  
Proton Therapy ◽  
Uniform Field ◽  
Pencil Beam ◽  
Proof Of Concept ◽  
Fixed Length ◽  
Spot Scanning ◽  
On Line

AbstractIn proton minibeam radiation therapy, proton minibeams are typically produced by modulating a uniform field using a multislit collimator. Multislit collimators produce minibeams of fixed length and width, and a new collimator has to be manufactured each time a new minibeam array is required, limiting its flexibility. In this work, we propose a scanning dynamic collimator for the generation of proton minibeams arrays. The new collimator system proposed is able to produce any minibeam required on an on-line basis by modulating the pencil beam spots of modern proton therapy machines, rather than a uniform field. The new collimator is evaluated through Monte Carlo simulations and the produced proton minibeams are compared with that of a multislit collimator. Furthermore, a proof of concept experiment is conducted to demonstrate the feasibility of producing a minibeam array by repositioning (i.e. scanning) a collimator. It is concluded that besides the technical challenges, the new collimator design is producing equivalent minibeam arrays to the multislit collimator, whilst is flexible to produce any minibeam array desired.

Spot-scanning beam proton therapy vs intensity-modulated radiation therapy for ipsilateral head and neck malignancies: A treatment planning comparison

2013 ◽  
Vol 38 (4) ◽  
pp. 390-394 ◽  
Author(s):  
Shravan Kandula ◽  
Xiaorong Zhu ◽  
Adam S. Garden ◽  
Michael Gillin ◽  
David I. Rosenthal ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Treatment Planning ◽  
Proton Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Head And Neck Malignancies ◽  
Intensity Modulated ◽  
Scanning Beam ◽  
Spot Scanning ◽  
Beam Proton

scholarly journals NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies – A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)

2016 ◽  
Vol 32 (9) ◽  
pp. 1095-1102 ◽  
Author(s):  
Takaaki Yoshimura ◽  
Rumiko Kinoshita ◽  
Shunsuke Onodera ◽  
Chie Toramatsu ◽  
Ryusuke Suzuki ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Hematologic Toxicity ◽  
Gynecologic Malignancies ◽  
Pelvic Radiation ◽  
Dosimetric Comparison ◽  
Spot Scanning ◽  
Modeling Analysis

Spot Scanning Based Proton Therapy for Skull Base Meningiomas: Long-Term Results from the Paul Scherrer Institute

2012 ◽  
Vol 73 (S 02) ◽  
Author(s):  
D. Weber ◽  
R. Schneider ◽  
T. Koch ◽  
J. Geismar ◽  
A. Schertler ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Paul Scherrer Institute ◽  
Long Term Results ◽  
Spot Scanning ◽  
Skull Base Meningiomas ◽  
Paul Scherrer

scholarly journals Three discipline collaborative radiation therapy (3DCRT) special debate: The United States should build additional proton therapy facilities

2019 ◽  
Vol 20 (2) ◽  
pp. 7-12 ◽  
Author(s):  
Steve Braunstein ◽  
Li Wang ◽  
Wayne Newhauser ◽  
Todd Tenenholz ◽  
Yi Rong ◽  
...  
Keyword(s):  
United States ◽  
Radiation Therapy ◽  
Proton Therapy ◽  
The United States

scholarly journals Early Clinical Outcomes of Intensity Modulated Radiation Therapy/Intensity Modulated Proton Therapy Combination in Comparison with Intensity Modulated Radiation Therapy Alone in Oropharynx Cancer Patients

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1549
Author(s):  
Han Gyul Yoon ◽  
Yong Chan Ahn ◽  
Dongryul Oh ◽  
Jae Myoung Noh ◽  
Seung Gyu Park ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Combination Group ◽  
Intensity Modulated Proton Therapy ◽  
Oropharynx Cancer ◽  
Intensity Modulated ◽  
Before And After ◽  
Grade 3 ◽  
Early Clinical Outcomes

Purpose: To report the early clinical outcomes of combining intensity-modulated radiation therapy (IMRT) and intensity-modulated proton therapy (IMPT) in comparison with IMRT alone in treating oropharynx cancer (OPC) patients. Materials and Methods: The medical records of 148 OPC patients who underwent definitive radiotherapy (RT) with concurrent systemic therapy, from January 2016 till December 2019 at Samsung Medical Center, were retrospectively reviewed. During the 5.5 weeks’ RT course, the initial 16 (or 18) fractions were delivered by IMRT in all patients, and the subsequent 12 (or 10) fractions were either by IMRT in 81 patients (IMRT only) or by IMPT in 67 (IMRT/IMPT combination), respectively, based on comparison of adaptive re-plan profiles and availability of equipment. Propensity-score matching (PSM) was done on 76 patients (38 from each group) for comparative analyses. Results: With the median follow-up of 24.7 months, there was no significant difference in overall survival and progression free survival between groups, both before and after PSM. Before PSM, the IMRT/IMPT combination group experienced grade ≥ 3 acute toxicities less frequently: mucositis in 37.0% and 13.4% (p < 0.001); and analgesic quantification algorithm (AQA) in 37.0% and 19.4% (p = 0.019), respectively. The same trends were observed after PSM: mucositis in 39.5% and 15.8% (p = 0.021); and AQA in 47.4% and 21.1% (p = 0.016), respectively. In multivariate logistic regression, grade ≥ 3 mucositis was significantly less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.027 and 0.024, respectively). AQA score ≥ 3 was also less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.085 and 0.018, respectively). Conclusions: In treating the OPC patients, with comparable early oncologic outcomes, more favorable acute toxicity profiles were achieved following IMRT/IMPT combination than IMRT alone.

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