MRI-targeted delivery of brain-penetrating non-viral gene nanoparticles across the blood–brain barrier with focused ultrasound: Neurodegenerative disease application

2016 ◽  
Vol 139 (4) ◽  
pp. 2092-2092
Author(s):  
Richard J. Price
Keyword(s):  
Neurodegenerative Disease ◽  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Viral Gene ◽  
Blood Brain

scholarly journals Nitrous Oxide Enhances Focused Ultrasound Mediated Delivery of Viral Gene Therapy

2021 ◽  
Author(s):  
Bhavya Ramesh Shah ◽  
Rachel M Bailey ◽  
Ibrahim Youssef ◽  
Sydni K Holmes ◽  
Austin Marckx ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Brain Regions ◽  
Brain Barrier ◽  
Viral Gene ◽  
Adeno Associated Virus ◽  
Blood Brain ◽  
Viral Gene Therapy

Transcranial Magnetic Resonance Guided Focused Ultrasound (MRgFUS) can be used in conjunction with intravenous microbubbles to open the blood brain barrier (BBB) in discrete brain regions. This method is limited by the microbubble dose, the amount of energy that can be safely delivered across an intact skull, and the inability to target areas of the brain outside of central brain regions. We find that N2O administration substantially decreases the required dose of microbubbles and/or focused ultrasound pressure while still reliably opening the blood brain barrier. Additionally, we observe that the use of nitrous oxide improves the delivery of adeno-associated virus (AAV9) vector when compared to medical air. Our findings may help overcome focused ultrasound limitations and improve targeted delivery of therapeutics in humans.

Targeted Delivery of GDNF Through the Blood-Brain Barrier by Mri-Guided Focused Ultrasound

2013 ◽  
Vol 39 (5) ◽  
pp. S26
Author(s):  
W. Feng ◽  
S. Yu ◽  
L. Lin ◽  
L. Li ◽  
C. Youli ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Mri Guided

Targeted Delivery of DNA-Au Nanoparticles across the Blood-Brain Barrier Using Focused Ultrasound

ChemMedChem ◽  
2018 ◽  
Vol 13 (13) ◽  
pp. 1311-1314 ◽  
Author(s):  
Tiffany G. Chan ◽  
Sophie V. Morse ◽  
Matthew J. Copping ◽  
James J. Choi ◽  
Ramon Vilar
Keyword(s):  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Au Nanoparticles ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Targeted Delivery of GDNF through the Blood–Brain Barrier by MRI-Guided Focused Ultrasound

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52925 ◽  
Author(s):  
Feng Wang ◽  
Yu Shi ◽  
Lin Lu ◽  
Li Liu ◽  
Youli Cai ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Mri Guided

Targeted delivery of antibodies through the blood–brain barrier by MRI-guided focused ultrasound

2006 ◽  
Vol 340 (4) ◽  
pp. 1085-1090 ◽  
Author(s):  
Manabu Kinoshita ◽  
Nathan McDannold ◽  
Ferenc A. Jolesz ◽  
Kullervo Hynynen
Keyword(s):  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Mri Guided

scholarly journals Magnetic Enhancement of Stem Cell–Targeted Delivery into the Brain Following MR-Guided Focused Ultrasound for Opening the Blood–Brain Barrier

2017 ◽  
Vol 26 (7) ◽  
pp. 1235-1246 ◽  
Author(s):  
Wei-Bin Shen ◽  
Pavlos Anastasiadis ◽  
Ben Nguyen ◽  
Deborah Yarnell ◽  
Paul J. Yarowsky ◽  
...  
Keyword(s):  
Stem Cell ◽  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Magnetic Enhancement ◽  
The Brain

scholarly journals Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27877 ◽  
Author(s):  
Alison Burgess ◽  
Carlos A. Ayala-Grosso ◽  
Milan Ganguly ◽  
Jessica F. Jordão ◽  
Isabelle Aubert ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Blood Brain Barrier ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Mri Guided ◽  
The Brain

scholarly journals Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yaoheng Yang ◽  
Xiaohui Zhang ◽  
Dezhuang Ye ◽  
Richard Laforest ◽  
Jeffrey Williamson ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Dose Painting ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption
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