An Investigation into the Prediction of the Plasma Concentration-Time Profile and Its Interindividual Variability for a Range of Flavin-Containing Monooxygenase Substrates Using a Physiologically Based Pharmacokinetic Modeling Approach

Modeling Approach ◽

Concentration Time ◽

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Journal of Pharmaceutical Sciences ◽

10.1002/jps.22550 ◽

2011 ◽

Vol 100 (10) ◽

pp. 4127-4157 ◽

Cited By ~ 115

Author(s):

Patrick Poulin ◽

Rhys D.O. Jones ◽

Hannah M. Jones ◽

Christopher R. Gibson ◽

Malcolm Rowland ◽

...

Keyword(s):

Plasma Concentration ◽

Predictive Models ◽

Human Pharmacokinetics ◽

Time Profiles ◽

Modeling Approach ◽

Concentration Time ◽

Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Modeling Approach ◽

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Frontiers in Pharmacology ◽

10.3389/fphar.2019.01672 ◽

2020 ◽

Vol 10 ◽

Cited By ~ 2

Author(s):

Jeffry Adiwidjaja ◽

Alan V. Boddy ◽

Andrew J. McLachlan

Keyword(s):

Drug Interactions ◽

Potential Drug ◽

Modeling Approach ◽

Optimal Dosing ◽

Physiologically Based ◽

Dosing Regimens

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2017.11.011 ◽

2018 ◽

Vol 112 ◽

pp. 168-179 ◽

Cited By ~ 28

Author(s):

Yumi Yamamoto ◽

Pyry A. Välitalo ◽

Yin Cheong Wong ◽

Dymphy R. Huntjens ◽

Johannes H. Proost ◽

...

Keyword(s):

Modeling Approach ◽

A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1992 ◽

2016 ◽

Vol 37 (1) ◽

pp. 15-27 ◽

Cited By ~ 8

Author(s):

Ian Templeton ◽

Paulien Ravenstijn ◽

Carlo Sensenhauser ◽

Jan Snoeys

Keyword(s):

Drug Interactions ◽

Modeling Approach ◽

A Physiologically-Based Pharmacokinetic Modeling Approach Using Biomonitoring Data in Order to Assess the Contribution of Drinking Water for the Achievement of an Optimal Fluoride Dose for Dental Health in Children

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15071358 ◽

2018 ◽

Vol 15 (7) ◽

pp. 1358 ◽

Cited By ~ 2

Author(s):

Keven Jean ◽

Nancy Wassef ◽

Fabien Gagnon ◽

Mathieu Valcke

Keyword(s):

Drinking Water ◽

Dental Health ◽

Modeling Approach ◽

A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients

Drug Metabolism and Disposition ◽

10.1124/dmd.116.073585 ◽

2017 ◽

Vol 45 (4) ◽

pp. 361-374 ◽

Cited By ~ 4

Author(s):

Heidi J. Einolf ◽

Jocelyn Zhou ◽

Christina Won ◽

Lai Wang ◽

Sam Rebello

Keyword(s):

Drug Interactions ◽

Cancer Patients ◽

Modeling Approach ◽

Evaluation of the Drug–Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP ‐5862, Using a Physiologically‐Based Pharmacokinetic Modeling Approach

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12408 ◽

2019 ◽

Vol 8 (7) ◽

pp. 489-499 ◽

Cited By ~ 1

Author(s):

Diansong Zhou ◽

Terry Podoll ◽

Yan Xu ◽

Ganesh Moorthy ◽

Karthick Vishwanathan ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Active Metabolite ◽

Modeling Approach ◽

Physiologically Based ◽

Drug Drug Interaction

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2013.79 ◽

2013 ◽

Vol 94 (2) ◽

pp. 260-268 ◽

Cited By ~ 49

Author(s):

K K Machavaram ◽

L M Almond ◽

A Rostami-Hodjegan ◽

I Gardner ◽

M Jamei ◽

...

Keyword(s):

Drug Interactions ◽

Modeling Approach ◽

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug-Drug Interactions of Buprenorphine After Subcutaneous Administration of CAM2038 With Perpetrators of CYP3A4

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.10.035 ◽

2018 ◽

Vol 107 (3) ◽

pp. 942-948

Author(s):

Tao Liu ◽

Jogarao V.S. Gobburu

Keyword(s):

Drug Interactions ◽

Subcutaneous Administration ◽

Modeling Approach ◽