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Author(s):  
Arunkumar Subramaniam ◽  
Nurru Anida Ibrahim ◽  
Siti Norbakyah Jabar ◽  
Salisa Abdul Rahman

<span>Driving cycle is commonly known as a series of speed-time profile. Research on this discipline aids vehicle manufacturing industries in vehicle manufacturing, environmentalists to study on environment quality and profile in accordance to vehicle emissions besides traffic engineers to further investigate the behavior of drivers and the conditions of roads in a certain area or cluster. This also assists automotive industries to innovate energy efficient vehicles which reduce vehicle emissions and energy wastages which lead to air pollution in which a major threat for human health according to Goal 3 of united nations (UN) sustainable development goals (SDG). To construct an accurate driving cycle, data based on real-world driving behavior is crucial and as the world is advancing in technology, the usage of internet of things (IoT) plays an important role in innovatietcons. IoT is an idea of computing every day physical object and information into computers, devices and software. These devices work by using sensors that transmit data to a computer or software allowing them to perform important tasks as needed. In this research, an idea of data collecting device, driving cycle tracking device (DC-TRAD) is constructed with implementation of IoT in which the collected data will be saved into my structured query language (MySQL) database instantly for data storing.</span>


2022 ◽  
pp. 097491012110622
Author(s):  
Yaser Ahmed Arabyat ◽  
Omar G. Aziz

The purpose of the study is to develop a theoretical model to ascertain if the IT investment in the banking sector is capable of generating a new equilibrium with increased efficiency. The empirical strategy is to seek an indirect test for Jordanian banking sector by looking at the time profile of banking profits as a temporal function of IT investment. The study enquires if the banking sector, as an iterative process of credit allocation and information acquisition through IT investment, lead to a stable equilibrium? Does IT investment ensure stable market shares for Jordanian banks in the long run? The study finds that investment in IT has led the banking system in Jordan away from an efficient equilibrium. We also find that the banks in Jordan directly interact with each other, although they may have collusive arrangements with some of their rivals, this means the banking market is not fragmented.


2022 ◽  
Vol 52 (1) ◽  
pp. 87-93
Author(s):  
D V Gorbatov ◽  
V A Konyshev ◽  
T O Lukinykh ◽  
O E Nanii ◽  
A G Novikov ◽  
...  

Abstract A numerical model is constructed for calculating lightning-induced rapid changes in the polarisation state of a light signal at the output of a fibre-optic communication line with an optical ground wire. It is shown that taking into account anisotropy of real optical fibres has a noticeable effect on the shape of the polarisation rotation speed time profile. It is found that the maximum rate of change in the polarisation state and its temporal profile depend on the location of the lightning strike in the fibre span, the magnitude of fibre anisotropy and the direction of propagation of a light wave.


2021 ◽  
Vol 12 ◽  
Author(s):  
Zhongxia Tan ◽  
Youxi Zhang ◽  
Chao Wang ◽  
Le Sun

The aim of this study was to develop physiologically based pharmacokinetic (PBPK) models capable of simulating cefadroxil concentrations in plasma and tissues in mouse, rat, and human. PBPK models in this study consisted of 14 tissues and 2 blood compartments. They were established using measured tissue to plasma partition coefficient (Kp) in mouse and rat, absolute expression levels of hPEPT1 along the entire length of the human intestine, and the transporter kinetic parameters. The PBPK models also assumed that all the tissues were well-stirred compartments with perfusion rate limitations, and the ratio of the concentration in tissue to the unbound concentration in plasma is identical across species. These PBPK models were validated strictly by a series of observed plasma concentration–time profile data. The average fold error (AFE) and absolute average fold error (AAFE) values were all less than 2. The models’ rationality and accuracy were further demonstrated by the almost consistent Vss calculated by the PBPK model and noncompartmental method, as well as the good allometric scaling relationship of Vss and CL. The model suggests that hPEPT1 is the major transporter responsible for the oral absorption of cefadroxil in human, and the plasma concentration–time profiles of cefadroxil were not sensitive to dissolution rate faster than T85% = 2 h. The cefadroxil PBPK model in human is reliable and can be used to predict concentration–time profile at infected tissue. It may be useful for dose selection and informative decision-making during clinical trials and dosage form design of cefadroxil and provide a reference for the PBPK model establishment of hPEPT1 substrate.


2021 ◽  
Author(s):  
Justyna M. Sokół ◽  
Maher Dayeh ◽  
Radoslav Bucik ◽  
Kim Moreland
Keyword(s):  

2021 ◽  
Vol 2021 (12) ◽  
pp. 053
Author(s):  
A. Sheshukov ◽  
A. Vishneva ◽  
A. Habig

Abstract Supernova neutrino detection in neutrino and dark matter experiments is usually implemented as a real-time trigger system based on counting neutrino interactions within a moving time window. The sensitivity reach of such experiments can be improved by taking into account the time profile of the expected signal. We propose a shape analysis of the incoming experimental data based on a log likelihood ratio variable containing the assumed signal shape. This approach also allows a combination of potential supernova signals in different detectors for a further sensitivity boost. The method is tested on the NOvA detectors to study their combined sensitivity to the core-collapse supernova signal, and also on KamLAND, Borexino and SK-Gd as potential detectors of presupernova neutrinos. Using the shape analysis enhances the signal significance for supernova detection and prediction, as well as the sensitivity reach of the experiment. It also extends the supernova prediction time when applied to the presupernova neutrino signal detection. Enhancements achieved with the shape analysis persist even in the case when the actual signal doesn't match the expected signal model.


2021 ◽  
Vol 11 (23) ◽  
pp. 11302
Author(s):  
Annalisa Mentana ◽  
Carmen Palermo ◽  
Diego Centonze

A method for the determination of β-agonists was developed by combining the separation of analytes through high-performance liquid chromatography, with a reversed-phase column, coupled to the pulsed amperometric detection at a glassy carbon electrode. Preliminary experiments, using cyclic voltammetry, allowed for an understanding of the electrochemical behavior of clenbuterol, fenoterol, and terbutaline. By analyzing the electrochemical response, the conditions for detecting the analytes and for cleaning the working electrode were identified. The proposed potential-time profile was designed to prevent contamination of the carbon electrode following consecutive analyses, so ensuring a reproducible and sensitive quantitative determination. The waveform electrochemical parameters, including detection and delay times, have been optimized in terms of sensitivity, detection limits, and long-term response stability. The chromatographic separation was carried out using a C8 column in isocratic mode, and a mixture of acetic acid and acetonitrile. The optimized experimental conditions were used for the analysis of standard solutions and real samples. Detection limits, lower than the maximum residue limit set for clenbuterol by European directives, were obtained for all β-agonists investigated. The method validation was performed by evaluating the linearity, selectivity, precision, and recovery. Calf urine samples were used to verify the applicability of the proposed method, analyzing both enriched and naturally contaminated urine samples.


Author(s):  
Marco Rabuffetti ◽  
Mathias Steinach ◽  
Julia Lichti ◽  
Hanns-Christian Gunga ◽  
Björn Balcerek ◽  
...  

Fatigue is a key factor that affects human motion and modulates physiology, biochemistry, and performance. Prolonged cyclic human movements (locomotion primarily) are characterized by a regular pattern, and this extended activity can induce fatigue. However, the relationship between fatigue and regularity has not yet been extensively studied. Wearable sensor methodologies can be used to monitor regularity during standardized treadmill tests (e.g., the widely used Bruce test) and to verify the effects of fatigue on locomotion regularity. Our study on 50 healthy adults [27 males and 23 females; &lt;40 years; five dropouts; and 22 trained (T) and 23 untrained (U) subjects] showed how locomotion regularity follows a parabolic profile during the incremental test, without exception. At the beginning of the trial, increased walking speed in the absence of fatigue is associated with increased regularity (regularity index, RI, a. u., null/unity value for aperiodic/periodic patterns) up until a peak value (RI = 0.909 after 13.8 min for T and RI = 0.915 after 13.4 min for U subjects; median values, n. s.) and which is then generally followed (after 2.8 and 2.5 min, respectively, for T/U, n. s.) by the walk-to-run transition (at 12.1 min for both T and U, n. s.). Regularity then decreases with increased speed/slope/fatigue. The effect of being trained was associated with significantly higher initial regularity [0.845 (T) vs 0.810 (U), p &lt; 0.05 corrected], longer test endurance [23.0 min (T) vs 18.6 min (U)], and prolonged decay of locomotor regularity [8.6 min (T) vs 6.5 min (U)]. In conclusion, the monitoring of locomotion regularity can be applied to the Bruce test, resulting in a consistent time profile. There is evidence of a progressive decrease in regularity following the walk-to-run transition, and these features unveil significant differences among healthy trained and untrained adult subjects.


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