Allosteric Modulation by Persistent Binding of Xanomeline of the Interaction of Competitive Ligands with the M1 Muscarinic Acetylcholine Receptor

Allosteric Modulation ◽

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease

Drug Discovery Today ◽

10.1016/j.drudis.2013.09.005 ◽

2013 ◽

Vol 18 (23-24) ◽

pp. 1185-1199 ◽

Cited By ~ 78

Author(s):

Bruce J. Melancon ◽

James C. Tarr ◽

Joseph D. Panarese ◽

Michael R. Wood ◽

Craig W. Lindsley

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Acetylcholine Receptor ◽

Allosteric Modulation ◽

Potential Treatment ◽

5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated Galpha(q) signalling in patients with psychiatric disorders

10.26226/morressier.5b68175eb56e9b005965c3a3 ◽

2018 ◽

Author(s):

Yuji Odagaki

Keyword(s):

Psychiatric Disorders ◽

Acetylcholine Receptor ◽

5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated activation of Gαq/11 in postmortem dorsolateral prefrontal cortex of opiate addicts

Pharmacological Reports ◽

10.1007/s43440-021-00248-w ◽

2021 ◽

Author(s):

Yuji Odagaki ◽

Masakazu Kinoshita ◽

J. Javier Meana ◽

Luis F. Callado ◽

Jesús A. García-Sevilla

Keyword(s):

Prefrontal Cortex ◽

Acetylcholine Receptor ◽

Dorsolateral Prefrontal Cortex ◽

Dorsolateral Prefrontal ◽

Opiate Addicts ◽

Pharmacological Assessment of M1 Muscarinic Acetylcholine Receptor-Gq/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.108.137968 ◽

2008 ◽

Vol 325 (3) ◽

pp. 869-874 ◽

Cited By ~ 20

Author(s):

Hasib Salah-Uddin ◽

David R. Thomas ◽

Ceri H. Davies ◽

Jim J. Hagan ◽

Martyn D. Wood ◽

...

Keyword(s):

Human Brain ◽

Brain Tissue ◽

Acetylcholine Receptor ◽

Human Brain Tissue ◽

Postmortem Human Brain ◽

Protein Coupling ◽

Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand‐binding affinity and signal transduction

The FASEB Journal ◽

10.1096/fj.201800936r ◽

2018 ◽

Vol 33 (3) ◽

pp. 3237-3251 ◽

Cited By ~ 3

Author(s):

Jianrong Xu ◽

Panpan Tan ◽

Hui Li ◽

Yongyao Cui ◽

Yu Qiu ◽

...

Keyword(s):

Signal Transduction ◽

Ligand Binding ◽

Binding Affinity ◽

Acetylcholine Receptor ◽

The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity

The EMBO Journal ◽

10.1093/emboj/16.15.4597 ◽

1997 ◽

Vol 16 (15) ◽

pp. 4597-4605 ◽

Cited By ~ 144

Author(s):

W. Tsai

Keyword(s):

Ion Channel ◽

Acetylcholine Receptor ◽

Egf Receptor ◽

Channel Activity ◽

P2-317: Suvn-i1312004, a novel M1 muscarinic acetylcholine receptor-positive allosteric modulator: Potential for the treatment of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.859 ◽

2015 ◽

Vol 11 (7S_Part_13) ◽

pp. P615-P616

Author(s):

Renny Abraham ◽

Ramkumar Subramanian ◽

Rajesh Babu Medapati ◽

Ravirala Venkateshwarlu ◽

Sumanth Yathavakilla ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Acetylcholine Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway

Journal of Cell Science ◽

10.1242/jcs.175547 ◽

2015 ◽

Vol 128 (22) ◽

pp. 4235-4245 ◽

Cited By ~ 8

Author(s):

L. Jiang ◽

A. Kosenko ◽

C. Yu ◽

L. Huang ◽

X. Li ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Surface Transport ◽

Kcnq Channels ◽

The M1-muscarinic acetylcholine receptor subtype is linked to the inositide cycle in rat brain synaptosomes

Biochemical Society Transactions ◽

10.1042/bst0141261 ◽

1986 ◽

Vol 14 (6) ◽

pp. 1261-1262

Author(s):

LUCIO A. A. VAN ROOIJEN ◽

WOLFGANG U. DOMPERT ◽

ERVIN HORVÁTH ◽

DAVID G. SPENCER ◽

JÖRG TRABER

Keyword(s):

Rat Brain ◽

Acetylcholine Receptor ◽

Receptor Subtype ◽

Rat Brain Synaptosomes ◽

Brain Synaptosomes ◽

Author response for "M1 muscarinic acetylcholine receptor‐mediated inhibition of GABA release from striatal medium spiny neurons onto cholinergic interneurons"

10.1111/ejn.15074/v3/response1 ◽

2020 ◽

Author(s):

Etsuko Suzuki ◽

Toshihiko Momiyama

Keyword(s):

Acetylcholine Receptor ◽

Gaba Release ◽

Author Response ◽

Medium Spiny Neurons ◽

Cholinergic Interneurons ◽

Spiny Neurons ◽