Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Allosteric Modulators ◽

In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.124701 ◽

2007 ◽

Vol 323 (1) ◽

pp. 147-156 ◽

Cited By ~ 96

Author(s):

Gentaroh Suzuki ◽

Naohiro Tsukamoto ◽

Hiroshi Fushiki ◽

Aki Kawagishi ◽

Masayuki Nakamura ◽

...

Keyword(s):

Glutamate Receptor ◽

Pharmacological Characterization and Modeling of the Binding Sites of Novel 1,3-Bis(pyridinylethynyl)benzenes as Metabotropic Glutamate Receptor 5-Selective Negative Allosteric Modulators

Molecular Pharmacology ◽

10.1124/mol.112.078808 ◽

2012 ◽

Vol 82 (5) ◽

pp. 929-937 ◽

Cited By ~ 29

Author(s):

Christina Mølck ◽

Kasper Harpsøe ◽

David E. Gloriam ◽

Rasmus P. Clausen ◽

Ulf Madsen ◽

...

Keyword(s):

Glutamate Receptor ◽

Binding Sites ◽

Allosteric Modulators ◽

In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5

Frontiers in Pharmacology ◽

10.3389/fphar.2018.00327 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 1

Author(s):

Sarah Beggiato ◽

Andrea C. Borelli ◽

Maria C. Tomasini ◽

M. Paola Castelli ◽

Nicholas Pintori ◽

...

Keyword(s):

Glutamate Receptor ◽

Functional Characterization ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

Faculty Opinions recommendation of Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732704940.793543297 ◽

2018 ◽

Author(s):

Dario Doller

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

G Protein Coupled Receptor ◽

X Ray ◽

Metabotropic Glutamate ◽

G Protein Coupled

Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators

Cell Chemical Biology ◽

10.1016/j.chembiol.2017.06.003 ◽

2017 ◽

Vol 24 (7) ◽

pp. 858-869.e5 ◽

Cited By ~ 9

Author(s):

Falgun Shah ◽

Antonia F. Stepan ◽

Alison O'Mahony ◽

Sharlene Velichko ◽

Alexandra E. Folias ◽

...

Keyword(s):

Glutamate Receptor ◽

Skin Toxicity ◽

Allosteric Modulators ◽

Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5

The AAPS Journal ◽

10.1208/s12248-017-0093-5 ◽

2017 ◽

Vol 19 (4) ◽

pp. 1235-1248 ◽

Cited By ~ 16

Author(s):

Yuemin Bian ◽

Zhiwei Feng ◽

Peng Yang ◽

Xiang-Qun Xie

Keyword(s):

Drug Design ◽

Glutamate Receptor ◽

In Silico ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Design Case ◽

Design Case Study

Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.10.050 ◽

2015 ◽

Vol 25 (24) ◽

pp. 5792-5796 ◽

Cited By ~ 5

Author(s):

John M. Ellard ◽

Andrew Madin ◽

Oliver Philps ◽

Mark Hopkin ◽

Scott Henderson ◽

...

Keyword(s):

Glutamate Receptor ◽

Preclinical Model ◽

Allosteric Modulators ◽

Improve Performance ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2

European Journal of Neuroscience ◽

10.1111/j.1460-9568.1995.tb00666.x ◽

1995 ◽

Vol 7 (4) ◽

pp. 622-629 ◽

Cited By ~ 49

Author(s):

P. J. Flor ◽

K. Lindauer ◽

I. Püttner ◽

D. Rüegg ◽

S. Lukic ◽

...

Keyword(s):

Molecular Cloning ◽

Glutamate Receptor ◽

Functional Expression ◽

Receptor Type ◽

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01722 ◽

2018 ◽

Vol 62 (1) ◽

pp. 207-222 ◽

Cited By ~ 34

Author(s):

John A. Christopher ◽

Zoltán Orgován ◽

Miles Congreve ◽

Andrew S. Doré ◽

James C. Errey ◽

...

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

G Protein Coupled Receptor ◽

X Ray ◽

Metabotropic Glutamate ◽

G Protein Coupled

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors - Advances in Pharmacology ◽

Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators

10.1016/bs.apha.2020.03.001 ◽

2020 ◽

pp. 35-58

Author(s):

Kirstie A. Bennett ◽

John A. Christopher ◽

Benjamin G. Tehan

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽