scholarly journals Direct brain recordings reveal prefrontal cortex dynamics of memory development

2018 ◽  
Vol 4 (12) ◽  
pp. eaat3702 ◽  
Author(s):  
E. L. Johnson ◽  
L. Tang ◽  
Q. Yin ◽  
E. Asano ◽  
N. Ofen
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Scene Perception ◽  
Declarative Memory ◽  
Memory Formation ◽  
Developing Brain ◽  
Memory Development ◽  
Temporal Precision ◽  
Frontal Activity

Prevailing theories link prefrontal cortex (PFC) maturation to the development of declarative memory. However, the precise spatiotemporal correlates of memory formation in the developing brain are not known. We provide rare intracranial evidence that the spatiotemporal propagation of frontal activity supports memory formation in children. Seventeen subjects (6.2 to 19.4 years) studied visual scenes in preparation for a recognition memory test while undergoing direct cortical monitoring. Earlier PFC activity predicted greater accuracy, and subsecond deviations in activity flow between subregions predicted memory formation. Activity flow between inferior and precentral sites was refined during adolescence, partially explaining gains in memory. In contrast, middle frontal activity predicted memory independent of age. These findings show with subsecond temporal precision that the developing PFC links scene perception and memory formation and underscore the role of the PFC in supporting memory development.

scholarly journals The Role of the Prefrontal Cortex in Recognition Memory and Memory for Source: An fMRI Study

NeuroImage ◽  
1999 ◽  
Vol 10 (5) ◽  
pp. 520-529 ◽  
Author(s):  
Michael D. Rugg ◽  
Paul C. Fletcher ◽  
Phyllis M-L. Chua ◽  
Raymond J. Dolan
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Fmri Study

scholarly journals Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Tuane Bazanella Sampaio ◽  
Naiani Ferreira Marques ◽  
Luisa Bandeira Binder ◽  
Carla Inês Tasca ◽  
Rui Daniel Prediger
Keyword(s):  
Prefrontal Cortex ◽  
Membrane Potential ◽  
Recognition Memory ◽  
Locus Coeruleus ◽  
Mitochondrial Membrane Potential ◽  
Mitochondrial Membrane ◽  
Membrane Damage ◽  
Memory Deficits ◽  
Parkinson’S Diseases

Degeneration of the locus coeruleus (LC), the main source of cerebral noradrenaline (NA), has been reported in diverse neurodegenerative diseases, including Parkinson’s diseases (PD). There is increasing evidence indicating the role of NA deficiency in the prefrontal cortex (PFC) and the development of early cognitive impairments in PD. Here, we evaluated whether a selective noradrenergic lesion of LC caused by 6-hydroxydopamine (6-OHDA) may induce memory deficits and neurochemical alterations in the PFC. Adult male Wistar rats received stereotaxic bilateral injections of 6-OHDA (5 μg/2 μl) into the LC, and two stainless-steel guide cannulas were implanted in the PFC. The SHAM group received just vehicle. To induce a selective noradrenergic lesion, animals received nomifensine (10 mg/kg), a dopamine transporter blocker, one hour before surgery. 6-OHDA-lesioned rats displayed impairments of the short- and long-term object recognition memory associated to reduced content of tyrosine hydroxylase in the LC. Neurochemical analysis revealed an altered mitochondrial membrane potential in LC. Regarding the PFC, an increased ROS production, cell membrane damage, and mitochondrial membrane potential disruption were observed. Remarkably, bilateral NA (1 μg/0.2 μl) infusion into the PFC restored the recognition memory deficits in LC-lesioned rats. These findings indicate that a selective noradrenergic LC lesion induced by 6-OHDA deregulates a noradrenergic network in the PFC, which could be involved in the early memory impairments observed in nondemented PD patients.

scholarly journals Insula to mPFC reciprocal connectivity differentially underlies novel taste neophobic response and learning

2021 ◽  
Author(s):  
Haneen Kayyal ◽  
Sailendrakumar Kolatt Chandran ◽  
Adonis Yiannakas ◽  
Nathaniel Gould ◽  
Mohammad Khamaisy ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sensory Information ◽  
Insular Cortex ◽  
Memory Formation ◽  
Intrinsic Properties ◽  
Insight Into ◽  
Taste Experience ◽  
Neophobic Response

To survive in an ever-changing environment, animals must detect and learn salient information. The anterior insular cortex (aIC) and medial prefrontal cortex (mPFC) are heavily implicated in salience and novelty processing, and specifically, the processing of taste sensory information. Here, we examined the role of aIC-mPFC reciprocal connectivity in novel taste neophobia and memory formation, in mice. Using pERK and neuronal intrinsic properties as markers for neuronal activation, and retrograde AAV (rAAV) constructs for connectivity, we demonstrate a correlation between aIC-mPFC activity and novel taste experience. Furthermore, by expressing inhibitory chemogenetic receptors in these projections, we show that aIC-to-mPFC activity is necessary for both taste neophobia and its attenuation. However, activity within mPFC-to-aIC projections is essential only for the neophobic reaction but not for the learning process. These results provide an insight into the cortical circuitry needed to detect, react to- and learn salient stimuli, a process critically involved in psychiatric disorders.

scholarly journals Role of Medial Prefrontal Cortex Serotonin 2A Receptors in the Control of Retrieval of Recognition Memory in Rats

2013 ◽  
Vol 33 (40) ◽  
pp. 15716-15725 ◽  
Author(s):  
P. Bekinschtein ◽  
M. C. Renner ◽  
M. C. Gonzalez ◽  
N. Weisstaub
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Medial Prefrontal Cortex ◽  
Serotonin 2A

scholarly journals The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams

2021 ◽  
Vol 22 (22) ◽  
pp. 12113
Author(s):  
Lucie Dixsaut ◽  
Johannes Gräff
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Memory Formation ◽  
Memory Storage ◽  
Long Term Memory ◽  
Brain Areas ◽  
Long Term Storage ◽  
And Storage

It is becoming increasingly apparent that long-term memory formation relies on a distributed network of brain areas. While the hippocampus has been at the center of attention for decades, it is now clear that other regions, in particular the medial prefrontal cortex (mPFC), are taking an active part as well. Recent evidence suggests that the mPFC—traditionally implicated in the long-term storage of memories—is already critical for the early phases of memory formation such as encoding. In this review, we summarize these findings, relate them to the functional importance of the mPFC connectivity, and discuss the role of the mPFC during memory consolidation with respect to the different theories of memory storage. Owing to its high functional connectivity to other brain areas subserving memory formation and storage, the mPFC emerges as a central hub across the lifetime of a memory, although much still remains to be discovered.

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