Streptomycin as an Antiviral Agent: Mode of Action

Abstract Baloxavir marboxil (formerly S-033188) is a prodrug of baloxavir acid (S-033447) and inhibits cap-dependent endonuclease, an essential protein involved in the initiation of viral transcription by cleaving capped mRNA bound to PB2. Its adverse event profile is comparable to oseltamivir but is still vulnerable to resistance. The single-dose baloxavir marboxil is an appealing antiviral regimen for the treatment of influenza among outpatients when compared with longer, twice-daily regimens of oral and inhaled neuraminidase inhibitors. This review focuses on the mode of action, antiviral activity, pharmacokinetics, clinical indications, and safety profiles of this drug. Considerations for formulary addition and its place in therapy are also discussed.

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878 PRE-CLINICAL CHARACTERISATION OF A NOVEL DIRECT ACTING ANTIVIRAL AGENT WITH A NEW MODE OF ACTION

Journal of Hepatology ◽

10.1016/s0168-8278(12)60890-3 ◽

2012 ◽

Vol 56 ◽

pp. S342

Author(s):

N. Wilsher ◽

S. Saalau-Bethell ◽

A. Woodhead ◽

A. Millemaggi ◽

B. Graham ◽

...

Keyword(s):

Mode Of Action ◽

Antiviral Agent ◽

Direct Acting Antiviral ◽

Direct Acting

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Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agent: Mode of action of the antiinflammatory effects.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.37.771 ◽

1989 ◽

Vol 37 (3) ◽

pp. 771-774 ◽

Cited By ~ 1

Author(s):

Toshio FUJIYOSHI ◽

Hiroyuki IIDA ◽

Motoya MURAKAMI ◽

Miho KUWASHIMA ◽

Toshio UEMATSU

Keyword(s):

Mode Of Action ◽

Antiinflammatory Agent ◽

Pharmacological Studies ◽

Agent Mode ◽

Antiinflammatory Effects

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Cerosomes as skin repairing agent: Mode of action studies with a model stratum corneum layer at liquid/air and liquid/solid interfaces

BBA Advances ◽

10.1016/j.bbadva.2021.100039 ◽

2021 ◽

pp. 100039

Author(s):

Fabio Strati ◽

Tetiana Muhkina ◽

Reinhard H.H. Neubert ◽

Lukas Opalka ◽

Gerd Hause ◽

...

Keyword(s):

Stratum Corneum ◽

Mode Of Action ◽

Agent Mode

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Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066917 ◽

1971 ◽

Vol 29 ◽

pp. 570-571

Author(s):

E. A. Elfont ◽

R. B. Tobin ◽

D. G. Colton ◽

M. A. Mehlman

Keyword(s):

Chemical Composition ◽

Rat Liver ◽

Future Study ◽

Mode Of Action ◽

Liver Mitochondria ◽

Rat Liver Mitochondria ◽

Effective Inhibitor ◽

Biochemical Effects ◽

Glycerophosphate Dehydrogenase ◽

Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

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