Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions

Science ◽  
1986 ◽  
Vol 234 (4778) ◽  
pp. 859-863 ◽  
Author(s):  
M Sharon ◽  
R. Klausner ◽  
B. Cullen ◽  
R Chizzonite ◽  
W. Leonard
Keyword(s):  
Interleukin 2 ◽  
Cross Linking ◽  
Receptor Subunit ◽  
High Affinity ◽  
Interleukin 2 Receptor

scholarly journals Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

1988 ◽  
Vol 167 (2) ◽  
pp. 612-622 ◽  
Author(s):  
P Bacha ◽  
D P Williams ◽  
C Waters ◽  
J M Williams ◽  
J R Murphy ◽  
...  
Keyword(s):  
T Cells ◽  
Protein Synthesis ◽  
T Cell ◽  
Diphtheria Toxin ◽  
Interleukin 2 ◽  
Elongation Factor ◽  
High Affinity ◽  
Interleukin 2 Receptor ◽  
Human T Cell ◽  
Inhibition Of Protein Synthesis

The IL-2 toxin-mediated inhibition of protein synthesis in high affinity IL-2-R-positive murine and human T cell lines has been examined. Both excess free IL-2 and mAb to the Tac epitope of the p55 subunit of IL-2-R are shown to block the action of IL-2 toxin; whereas, agents that interact with other receptors or antigens on the T cell surface have no effect. We show that IL-2 toxin, like diphtheria toxin, must pass through an acidic vesicle in order to intoxicate target T cells. Finally, we demonstrate that the IL-2 toxin-mediated inhibition of protein synthesis in both human and murine T cells that bear the high affinity IL-2-R is due to the classic diphtheria toxin fragment A-catalyzed ADP ribosylation of elongation factor 2.

scholarly journals Solution assembly of the pseudo-high affinity and intermediate affinity interleukin-2 receptor complexes

2008 ◽  
Vol 8 (3) ◽  
pp. 482-489 ◽  
Author(s):  
Zining Wu ◽  
Byron Goldstein ◽  
Thomas M. Laue ◽  
Stefano F. Liparoto ◽  
Michael J. Nemeth ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Receptor Complexes ◽  
High Affinity ◽  
Interleukin 2 Receptor

Interleukin-2 Receptor Subunit Expression and Function on Human Peripheral T Cells Is Not Dependent on the Anticoagulant

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2989-2993 ◽  
Author(s):  
Guido L. Vanham ◽  
Godelieve Penne ◽  
Chris Vereecken ◽  
Johan Vingerhoets ◽  
Luc Kestens
Keyword(s):  
T Cells ◽  
Interleukin 2 ◽  
Receptor Subunit ◽  
Interleukin 2 Receptor ◽  
Peripheral T Cells ◽  
Subunit Expression ◽  
And Function

Interleukin-2 Receptor Subunit Expression and Function on Human Peripheral T Cells Is Not Dependent on the Anticoagulant

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2989-2993
Author(s):  
Guido L. Vanham ◽  
Godelieve Penne ◽  
Chris Vereecken ◽  
Johan Vingerhoets ◽  
Luc Kestens
Keyword(s):  
T Cells ◽  
Interleukin 2 ◽  
Receptor Subunit ◽  
Interleukin 2 Receptor ◽  
Peripheral T Cells ◽  
Subunit Expression ◽  
And Function

Stepwise formation of the high-affinity complex of the interleukin 2 receptor

1990 ◽  
Vol 2 (12) ◽  
pp. 1167-1177 ◽  
Author(s):  
Yuji Saito ◽  
Toshihiko Ogura ◽  
Masanori Kamio ◽  
Hisataka Sabe ◽  
Takashi Uchiyama ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
High Affinity ◽  
Interleukin 2 Receptor ◽  
Stepwise Formation
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