scholarly journals An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Science ◽  
2021 ◽  
Author(s):  
Dafydd R. Owen ◽  
Charlotte M. N. Allerton ◽  
Annaliesa S. Anderson ◽  
Lisa Aschenbrenner ◽  
Melissa Avery ◽  
...  
Keyword(s):  
Clinical Candidate

Chemical optimization of Pneumocandin B0 and selection of the pre-clinical candidate Caspofungin

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
JM Balkovec ◽  
RM Black ◽  
FA Bouffard ◽  
JF Dropinski ◽  
ML Hammond ◽  
...  
Keyword(s):  
Selection Of ◽  
Clinical Candidate

scholarly journals Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform

mAbs ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 666-680 ◽  
Author(s):  
Torben Gjetting ◽  
Monika Gad ◽  
Camilla Fröhlich ◽  
Trine Lindsted ◽  
Maria C Melander ◽  
...  
Keyword(s):  
Antibody Discovery ◽  
Clinical Candidate

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320

2015 ◽  
Vol 25 (22) ◽  
pp. 5427-5436 ◽  
Author(s):  
Christophe C. Parsy ◽  
François-René Alexandre ◽  
Valérie Bidau ◽  
Florence Bonnaterre ◽  
Guillaume Brandt ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protease Inhibitor ◽  
Serine Protease ◽  
Structural Diversity ◽  
Serine Protease Inhibitor ◽  
Clinical Candidate

scholarly journals Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse

MedChemComm ◽  
2013 ◽  
Vol 4 (3) ◽  
pp. 564 ◽  
Author(s):  
Guangrong Zheng ◽  
David B. Horton ◽  
Narsimha Reddy Penthala ◽  
Justin R. Nickell ◽  
John P. Culver ◽  
...  
Keyword(s):  
Methamphetamine Abuse ◽  
Clinical Candidate

scholarly journals Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes

2011 ◽  
Vol 2 (11) ◽  
pp. 824-827 ◽  
Author(s):  
Aiwen Li ◽  
Chester C. Yuan ◽  
David Chow ◽  
Michelle Chen ◽  
Maurice G. Emery ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Candidate

scholarly journals Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

2018 ◽  
Vol 9 (7) ◽  
pp. 623-628 ◽  
Author(s):  
Hilary Schenck Eidam ◽  
John Russell ◽  
Kaushik Raha ◽  
Michael DeMartino ◽  
Donghui Qin ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Clinical Candidate

scholarly journals Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

2012 ◽  
Vol 287 (49) ◽  
pp. 41245-41257 ◽  
Author(s):  
Fredrik Jeppsson ◽  
Susanna Eketjäll ◽  
Juliette Janson ◽  
Sofia Karlström ◽  
Susanne Gustavsson ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Bace1 Inhibitor ◽  
Clinical Candidate

BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate

2021 ◽  
Author(s):  
Robert J. Cherney ◽  
Prakash Anjanappa ◽  
Kumaravel Selvakumar ◽  
Douglas G. Batt ◽  
Gregory D. Brown ◽  
...  
Keyword(s):  
Clinical Candidate
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