scholarly journals Location, location, location: Tissue resident memory T cells in mice and humans

2019 ◽  
Vol 4 (34) ◽  
pp. eaas9673 ◽  
Author(s):  
Peter A. Szabo ◽  
Michelle Miron ◽  
Donna L. Farber
Keyword(s):  
T Cells ◽  
Adaptive Immunity ◽  
Mouse Models ◽  
Memory T Cells ◽  
The Body ◽  
Human Studies ◽  
Tissue Sampling ◽  
Site Specific ◽  
Functional Features ◽  
Resident Memory T Cells

The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity to encompass site-specific responses mediated by tissue-adapted memory T cells throughout the body. Here, we discuss the key phenotypic, transcriptional, and functional features of these tissue-resident memory T cells (TRM) as established in mouse models of infection and translated to humans by novel tissue sampling approaches. Integration of findings from mouse and human studies may hold the key to unlocking the potential of TRM for promoting tissue immunity and preventing infection.

scholarly journals Resident Memory T Cells and Their Role within the Liver

2020 ◽  
Vol 21 (22) ◽  
pp. 8565
Author(s):  
Sonia Ghilas ◽  
Ana-Maria Valencia-Hernandez ◽  
Matthias H. Enders ◽  
William R. Heath ◽  
Daniel Fernandez-Ruiz
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Plasmodium Species ◽  
Immunological Memory ◽  
Cellular Responses ◽  
The Body ◽  
Entire Body ◽  
Memory Cells ◽  
Peripheral Tissues ◽  
Resident Memory T Cells

Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses—the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (TRM) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, TRM cells provide a frontline defense against reinfection. Here, we review this population of cells with specific attention to the liver, where TRM cells have been found to protect against infections, in particular those by Plasmodium species that cause malaria.

scholarly journals Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice withBordetella pertussis

2017 ◽  
Vol 199 (1) ◽  
pp. 233-243 ◽  
Author(s):  
Mieszko M. Wilk ◽  
Alicja Misiak ◽  
Róisín M. McManus ◽  
Aideen C. Allen ◽  
Marina A. Lynch ◽  
...  
Keyword(s):  
T Cells ◽  
Adaptive Immunity ◽  
Memory T Cells ◽  
Previous Infection ◽  
Resident Memory T Cells

scholarly journals Resident Memory T Cells in Autoimmune Skin Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Grace E. Ryan ◽  
John E. Harris ◽  
Jillian M. Richmond
Keyword(s):  
T Cells ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Memory T Cells ◽  
Cutaneous Lupus Erythematosus ◽  
The Body ◽  
Specific Response ◽  
Peripheral Tissues ◽  
Skin Conditions ◽  
Resident Memory T Cells

Tissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that TRM cells also form during autoimmunity. TRM mediated autoimmune diseases are particularly destructive, because unlike foreign antigens, the self-antigens are never cleared, continuously activating self-reactive TRM T cells. In this article, we will focus on how TRMs mediate disease in autoimmune skin conditions, specifically vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata and frontal fibrosing alopecia.

Author response for "White matter lesions in multiple sclerosis are enriched for CD20 dim CD8 + tissue‐resident memory T cells"

2020 ◽  
Author(s):  
Cheng‐Chih Hsiao ◽  
Nina L. Fransen ◽  
Aletta M.R. den Bosch ◽  
Kim I.M. Brandwijk ◽  
Inge Huitinga ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
White Matter ◽  
Memory T Cells ◽  
White Matter Lesions ◽  
Author Response ◽  
Resident Memory T Cells

Author response for "Circulating memory CD8 + T cells are limited in forming CD103 + tissue‐resident memory T cells at mucosal sites after reinfection"

2020 ◽  
Author(s):  
Felix M. Behr ◽  
Ammarina Beumer‐Chuwonpad ◽  
Natasja A.M. Kragten ◽  
Thomas H. Wesselink ◽  
Regina Stark ◽  
...  
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Author Response ◽  
Resident Memory T Cells
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