In vitro kill curves of a new semisynthetic echinocandin, LY-303366, against fluconazole-sensitive and -resistant Candida species.
1997 ◽
Vol 41
(11)
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pp. 2576-2578
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Keyword(s):
In vitro killing by a new semisynthetic echinocandin, LY-303366, was characterized using clinical isolates of fluconazole-sensitive (Y58) and -resistant (Y180) Candida albicans as well as Candida glabrata (Y7) and Candida krusei (Y171). The 24-h kill curves for Y58 and Y180 demonstrated dose-independent killing of between 1 and 2 log10 with LY-303366 at concentrations of 0.1, 1, 10, 50, 100, and 1,000 times the MIC. Regrowth did not occur at 24 h with either C. albicans isolate at the aforementioned LY-303366 concentrations. At their MICs, LY-303366 and amphotericin B produced similar killing kinetics in cultures of Y58, Y180, Y7, and Y171, while all cultures exposed to fluconazole at its MIC demonstrated stasis or growth over 24 h.
1998 ◽
Vol 42
(11)
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pp. 3012-3013
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Keyword(s):
2001 ◽
Vol 45
(6)
◽
pp. 1905-1907
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2002 ◽
Vol 46
(5)
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pp. 1240-1245
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Keyword(s):
2009 ◽
Vol 15
(1)
◽
pp. 1-5
◽
2010 ◽
Vol 43
(6)
◽
pp. 673-677
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Keyword(s):
2021 ◽
Vol 54
(1)
◽
pp. e168684
Keyword(s):