In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide

ABSTRACT 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis,Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.

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In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates

International Journal of Antimicrobial Agents ◽

10.1016/j.ijantimicag.2006.02.011 ◽

2006 ◽

Vol 28 (1) ◽

pp. 75-78 ◽

Cited By ~ 30

Author(s):

M. Tato ◽

E. Gómez-G. de la Pedrosa ◽

R. Cantón ◽

I. Gómez-García ◽

J. Fortún ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Mycobacterium Bovis ◽

Mycobacterium Tuberculosis Complex ◽

Multidrug Resistant ◽

Vitro Activity ◽

In Vitro Activity ◽

Tuberculosis Complex

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Antimycobacterial 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones substituted on phenyl and benzoxazine moiety in position 6

Chemical Papers ◽

10.2478/s11696-011-0020-7 ◽

2011 ◽

Vol 65 (3) ◽

Cited By ~ 2

Author(s):

Eva Petrlíková ◽

Karel Waisser ◽

Rafael Doležal ◽

Pavel Holý ◽

Jiří Gregor ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Antimycobacterial Activity ◽

Vitro Activity ◽

In Vitro Activity ◽

Derivatives Of

AbstractA series of forty-five derivatives of 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and forty-five derivatives of 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones was synthesised. The compounds exhibited in-vitro activity against Mycobacterium tuberculosis, M. kansasii (two strains), and M. avium. The most active derivatives were more active than isonicotinhydrazide (INH). The quantitative relationships between the structure and antimycobacterial activity were calculated. The activity against M. tuberculosis increased with the lipophilicity of the substituents.

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Enhanced in vitro activity of WR99210 in combination with dapsone against Mycobacterium avium complex.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.40.11.2644 ◽

1996 ◽

Vol 40 (11) ◽

pp. 2644-2645 ◽

Cited By ~ 7

Author(s):

L M Shah ◽

M S DeStefano ◽

M H Cynamon

Keyword(s):

Dihydrofolate Reductase ◽

Mycobacterium Avium ◽

Mycobacterium Avium Complex ◽

Reductase Inhibitor ◽

Vitro Activity ◽

Dilution Method ◽

In Vitro Activity ◽

Fixed Concentration ◽

Broth Dilution

WR99210, a dihydrofolate reductase inhibitor, has promising in vitro activity against Mycobacterium avium complex (MAC). The in vitro activities of WR99210 alone and in combination with a fixed concentration of dapsone (0.5 microgram/ml) were evaluated against 35 clinical MAC isolates by a broth dilution method. The MIC at which 50% of isolates were inhibited (MIC50) and MIC90 of WR99210 alone were 2 and 8 micrograms/ml, respectively. The MIC50 and MIC90 of WR99210 in combination with dapsone were 0.25 and 4 micrograms/ml, respectively. Overall, 75% of the MAC isolates displayed enhanced susceptibility to the combination.

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Essential Oils from two Lantana species with Antimycobacterial Activity

Natural Product Communications ◽

10.1177/1934578x0900401224 ◽

2009 ◽

Vol 4 (12) ◽

pp. 1934578X0900401

Author(s):

Lisieux de Santana Julião ◽

Humberto R. Bizzo ◽

Andressa M. Souza ◽

Maria Cristina S. Lourenço ◽

Pedro Eduardo A. Silva ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Essential Oils ◽

Folk Medicine ◽

Antimycobacterial Activity ◽

Vitro Activity ◽

In Vitro Activity ◽

Respiratory Disorders ◽

Germacrene D ◽

Main Components

Lantana trifolia L. and L. fucata Lindl. are two Brazilian species used in folk medicine for the treatment of respiratory disorders. The composition of the essential oils from the leaves was investigated, as well as their in vitro activity against Mycobacterium tuberculosis. L. trifolia yielded an oil (0.2%) rich in sesquiterpenes. The major substances found were germacrene D (45.1%), (E)-caryophyllene (12.8%), bicyclogermacrene (12.7%) and α-humulene (4.4%). Sesquiterpenes were also the main components of the oil of L. fucata (0.3% yield), the principal ones being β-elemene (27.1%), germacrene D (11.6%), (E)-caryophyllene (7.7%), valencene (5.7%) and germacrene A (4.6%). Both oils exhibited in vitro antimycobacterial activity by the MABA assay with MICs of 80 μg/mL for L. trifolia and 100 μg/mL for L. fucata.

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