Hydroxyurea Enhances the Activities of Didanosine, 9-[2-(Phosphonylmethoxy)ethyl]adenine, and 9-[2-(Phosphonylmethoxy)propyl]adenine against Drug-Susceptible and Drug-Resistant Human Immunodeficiency Virus Isolates
1999 ◽
Vol 43
(8)
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pp. 2046-2050
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Keyword(s):
ABSTRACT We assessed the effects of hydroxyurea (HU) at a concentration of 50 μM on the in vitro activities of 2′,3′-dideoxyinosine (ddI), 9-[2-(phosphonylmethoxy)ethyl]adenine (PMEA), and 9-[2-(phosphonylmethoxy)propyl]adenine (PMPA) against a wild-type human immunodeficiency virus (HIV) type 1 (HIV-1) laboratory isolate and a panel of five well-characterized drug-resistant HIV isolates. Fifty micromolar HU significantly increased the activities of ddI, PMEA, and PMPA against both the wild-type and the drug-resistant HIV-1 isolates. In fixed combinations, both ddI and PMEA were synergistic with HU against wild-type and drug-resistant viruses.
2007 ◽
Vol 51
(11)
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pp. 4036-4043
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1999 ◽
Vol 43
(10)
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pp. 2376-2382
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2005 ◽
Vol 49
(11)
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pp. 4546-4554
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2002 ◽
Vol 76
(15)
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pp. 7398-7406
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2004 ◽
Vol 78
(9)
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pp. 4628-4637
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Keyword(s):
Interaction of Human Immunodeficiency Virus-Derived Vectors with Wild-Type Virus in Transduced Cells
1999 ◽
Vol 73
(8)
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pp. 7087-7092
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Keyword(s):
2011 ◽
Vol 55
(11)
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pp. 5090-5098
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2008 ◽
Vol 52
(4)
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pp. 1337-1344
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