scholarly journals Chimeric Derivatives of Hepatitis B Virus Core Particles Carrying Major Epitopes of the Rubella Virus E1 Glycoprotein

2013 ◽  
Vol 20 (11) ◽  
pp. 1719-1728 ◽  
Author(s):  
Dace Skrastina ◽  
Ivars Petrovskis ◽  
Rasa Petraityte ◽  
Irina Sominskaya ◽  
Velta Ose ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Rubella Virus ◽  
Scattering Data ◽  
Content Type ◽  
Antigenic Activity ◽  
Virus Core ◽  
E1 Protein ◽  
Virus Like Particle ◽  
B Virus

ABSTRACTThree variants of the major rubella virus (RV) E1 protein virus-neutralizing epitope from position 214 to 285 were exposed on the hepatitis B virus (HBV) C-terminally truncated core (HBcΔ) in a virus-like particle (VLP) vector and were produced inEscherichia coli. All three chimeras demonstrated VLPs in bacterial cell lysates, but only HBcΔ-E1(245-285) demonstrated the correct VLP structure after purification. The other chimeras, HBcΔ-E1(214-285) and HBcΔ-E1(214-240), appeared after purification as non-VLP aggregates of 100 to 900 nm in diameter according to dynamic light scattering data. All three variants possessed the intrinsic antigenic activity of RV E1, since they were recognized by natural human anti-RV E1 antibodies and induced an anti-RV E1 response in mice. HBcΔ-E1(214-240) and HBcΔ-E1(245-285) can be regarded as prototypes for a putative RV vaccine because they were able to induce antibodies recognizing natural RV E1 protein in RV diagnostic kits.

scholarly journals Structure of hepatitis B virus core and e-antigen. A single precore amino acid prevents nucleocapsid assembly.

1993 ◽  
Vol 268 (2) ◽  
pp. 1332-1337
Author(s):  
F. Schödel ◽  
D. Peterson ◽  
J. Zheng ◽  
J.E. Jones ◽  
J.L. Hughes ◽  
...  
Keyword(s):  
Amino Acid ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Core ◽  
B Virus ◽  
Antigen A

Hepatitis B Virus Core Particles as a Vaccine Carrier Moiety

1994 ◽  
Vol 11 (2) ◽  
pp. 153-165 ◽  
Author(s):  
Florian Schodel ◽  
T. Darell Peterson ◽  
Janice Hughes ◽  
David Milich
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Core ◽  
B Virus ◽  
Vaccine Carrier ◽  
Core Particles

Safety of using hepatitis B virus core antibody or surface antigen-positive donors in kidney or pancreas transplantation

2005 ◽  
Vol 19 (3) ◽  
pp. 364-366 ◽  
Author(s):  
Enver Akalin ◽  
Scott Ames ◽  
Vinita Sehgal ◽  
Barbara Murphy ◽  
Jonathan S Bromberg
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Pancreas Transplantation ◽  
Virus Core ◽  
B Virus
Sign in / Sign up

Export Citation Format

Share Document