Immunity to pathogenic free-living amoebae: role of humoral antibody

1980 ◽  
Vol 29 (2) ◽  
pp. 401-407 ◽  
Author(s):  
R T Cursons ◽  
T J Brown ◽  
E A Keys ◽  
K M Moriarty ◽  
D Till
Keyword(s):  
New Zealand ◽  
Immunoglobulin M ◽  
Host Susceptibility ◽  
Free Living ◽  
Protective Mechanisms ◽  
Susceptibility Factors ◽  
Human Sera ◽  
Normal Human ◽  
Health Districts

Pathogenic free-living amoebae are common in nature, but few clinical infections by these amoebae have been reported. This has prompted studies of host susceptibility factors in humans. A survey of normal human sera from three New Zealand Health Districts was made; antibodies to pathogenic free-living amoebae were found in all sera, with titers ranging from 1:5 to 1:20 for Naegleria spp. and from 1:20 to 1:80 for Acanthamoeba spp. The antibodies belonged mainly to immunoglobulin G and immunoglobulin M classes. The presence of a specific neutralizing factor against Acanthamoeba spp. but not Naegleria spp. was demonstrated. Possible protective mechanisms are discussed.

scholarly journals Host Alternative NADH:Ubiquinone Oxidoreductase Serves as a Susceptibility Factor to Promote Pathogenesis of Rhizoctonia solani in Plants

2019 ◽  
Vol 109 (10) ◽  
pp. 1741-1750 ◽  
Author(s):  
Ravi Kant ◽  
Kriti Tyagi ◽  
Srayan Ghosh ◽  
Gopaljee Jha
Keyword(s):  
Rhizoctonia Solani ◽  
Host Susceptibility ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Virus Induced Gene Silencing ◽  
Antioxidant Genes ◽  
Susceptibility Factor ◽  
Susceptibility Factors ◽  
Species Optimum ◽  
Isoflavone Reductase

Phytopathogens have evolved mechanisms to utilize host genes (commonly known as susceptibility factors) to promote their pathogenesis. Rhizoctonia solani is a highly destructive fungal pathogen of various plants, including rice. We previously reported rice genes that were differentially regulated during R. solani pathogenesis. In this study, we analyzed the role of tomato homologs of two rice genes, isoflavone reductase (IFR) and alternative NADH:ubiquinone oxidoreductase (NUOR), as potential susceptibility factors for R. solani. Virus-induced gene silencing of NUOR in tomato resulted in compromised susceptibility against R. solani, whereas IFR-silenced plants demonstrated susceptibility similar to that of control plants. NUOR silencing in tomato led to homogenous accumulation of reactive oxygen species (optimum range) upon R. solani infection. In addition, the expression and enzyme activity of some host defense and antioxidant genes was enhanced, whereas H2O2 content, lipid peroxidation, and electrolyte leakage were reduced in NUOR-silenced plants. Similarly, transient silencing of OsNUOR provided tolerance against R. solani infection in rice. Overall, the data presented in this study suggest that NUOR serves as a host susceptibility factor to promote R. solani pathogenesis.

scholarly journals Role of Alginate O Acetylation in Resistance of Mucoid Pseudomonas aeruginosa to Opsonic Phagocytosis

2001 ◽  
Vol 69 (3) ◽  
pp. 1895-1901 ◽  
Author(s):  
Gerald B. Pier ◽  
Fadie Coleman ◽  
Martha Grout ◽  
Michael Franklin ◽  
Dennis E. Ohman
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Molecular Basis ◽  
Host Defenses ◽  
Specific Antibodies ◽  
Human Sera ◽  
Normal Human ◽  
Lung Infections

ABSTRACT Establishment and maintenance of chronic lung infections with mucoid Pseudomonas aeruginosa in patients with cystic fibrosis (CF) require that the bacteria avoid host defenses. Elaboration of the extracellular, O-acetylated mucoid exopolysaccharide, or alginate, is a major microbial factor in resistance to immune effectors. Here we show that O acetylation of alginate maximizes the resistance of mucoid P. aeruginosa to antibody-independent opsonic killing and is the molecular basis for the resistance of mucoid P. aeruginosa to normally nonopsonic but alginate-specific antibodies found in normal human sera and sera of infected CF patients. O acetylation of alginate appears to be critical for P. aeruginosa resistance to host immune effectors in CF patients.

IMMUNOLOGICAL REACTIVITY OF INSULIN IN HUMAN SERUM

1966 ◽  
Vol 53 (4) ◽  
pp. 673-680 ◽  
Author(s):  
Torsten Deckert ◽  
Kai R. Jorgensen
Keyword(s):  
Normal Subjects ◽  
The Other ◽  
Human Pancreas ◽  
Porcine Pancreas ◽  
Crystalline Insulin ◽  
Endogenous Insulin ◽  
Significant Difference ◽  
Human Sera ◽  
Normal Human ◽  
The One

ABSTRACT The purpose of this study was to investigate whether a difference could be demonstrated between crystalline insulin extracted from normal human pancreas, and crystalline insulin extracted from bovine and porcine pancreas. Using Hales & Randle's (1963) immunoassay no immunological differences could be demonstrated between human and pig insulin. On the other hand, a significant difference was found, between pig and ox insulin. An attempt was also made to determine whether an immunological difference could be demonstrated between crystalline pig insulin and crystalline human insulin from non diabetic subjects on the one hand and endogenous, circulating insulin from normal subjects, obese subjects and diabetic subjects on the other. No such difference was found. From these experiments it is concluded that endogenous insulin in normal, obese and diabetic human sera is immunologically identical with human, crystalline insulin from non diabetic subjects and crystalline pig insulin.

Information-seeking to Support Personal and Community Wellbeing: Report of a study of New Zealand Men Using Focus Groups

2016 ◽  
Author(s):  
Peta Wellstead
Keyword(s):  
New Zealand ◽  
Focus Groups ◽  
Support Services ◽  
Information Seeking ◽  
Service Providers ◽  
Structural Constraints ◽  
Health And Wellbeing ◽  
Study Results ◽  
Groupes De Discussion

This paper reports part of an ongoing study exploring the information behaviour of New Zealand men during periods of diminished health and wellbeing. Focus groups were used for this iteration of the study. Results indicate that New Zealand men face both personal and structural constraints to their information-seeking during periods when their health and wellbeing may be compromised. This study highlights that service providers need to develop more effective information delivery mechanisms and support services for men. These services need to be appealing to men and reflect men’s information seeking preferences. The role of LIS professionals in supporting this endeavour is discussed. Cet article présente une étude en cours explorant le comportement informationnel d’ hommes néo-zélandais durant des périodes où leur état de santé et de bien-être est amoindri. Des groupes de discussion ont été utilisés pour cette itération de l'étude. Les résultats indiquent que les hommes en Nouvelle-Zélande font face à des contraintes à la fois  personnelles et structurelles dans leur recherche d'information pendant les périodes où leur santé et leur bien-être peuvent être affaiblis. Cette étude met en évidence le besoin pour les fournisseurs de services de développer des mécanismes de diffusion de l'information plus efficaces et des services de soutien pour les hommes. Ces services doivent être attrayants et refléter les préférences des hommes dans leurs recherches d’information. Le rôle des professionnels de l'information dans le soutien à cette entreprise est discuté.

Literary Histories

2018 ◽  
Author(s):  
Eva-Marie Kröller
Keyword(s):  
New Zealand ◽  
Collective Identity ◽  
Literary History ◽  
English Language ◽  
South Pacific ◽  
The South ◽  
Cultural Elite ◽  
Historical Methodology ◽  
Literary Histories

This chapter discusses national literary histories in Australia, Canada, New Zealand, and the South Pacific and summarises the book's main findings regarding the construction and revision of narratives of national identity since 1950. In colonial and postcolonial cultures, literary history is often based on a paradox that says much about their evolving sense of collective identity, but perhaps even more about the strains within it. The chapter considers the complications typical of postcolonial literary history by focusing on the conflict between collective celebration and its refutation. It examines three issues relating to the histories of English-language fiction in Australia, Canada, New Zealand, and the South Pacific: problems of chronology and beginnings, with a special emphasis on Indigenous peoples; the role of the cultural elite and the history wars in the Australian context; and the influence of postcolonial networks on historical methodology.

scholarly journals Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy

2021 ◽  
Vol 91 (S2) ◽  
pp. 3-13
Author(s):  
B. Mark Smithers ◽  
Robyn P. M. Saw ◽  
David E. Gyorki ◽  
Richard C. W. Martin ◽  
Victoria Atkinson ◽  
...  
Keyword(s):  
New Zealand ◽  
Systemic Therapy ◽  
Advanced Melanoma ◽  
Adjuvant Systemic Therapy ◽  
Contemporary Management
Sign in / Sign up

Export Citation Format

Share Document