Mutator Phenotype Resulting from DNA Polymerase IV Overproduction in Escherichia coli: Preferential Mutagenesis on the Lagging Strand
2005 ◽
Vol 187
(19)
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pp. 6862-6866
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ABSTRACT We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from extension of mismatches produced by polymerase III holoenzyme.
1998 ◽
Vol 180
(21)
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pp. 5712-5717
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Keyword(s):
Keyword(s):
Escherichia coli DNA Polymerase IV Mutator Activity: Genetic Requirements and Mutational Specificity
2000 ◽
Vol 182
(16)
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pp. 4587-4595
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Keyword(s):
Pol Iv
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2002 ◽
Vol 499
(1)
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pp. 97-101
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Keyword(s):
1995 ◽
pp. 442-449
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1992 ◽
Vol 267
(6)
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pp. 4064-4073
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