scholarly journals Evaluation of a rapid antigen test to detect SARS-CoV-2 infection and identify potentially infectious individuals

2021 ◽  
Author(s):  
Michael Korenkov ◽  
Nareshkumar Poopalasingam ◽  
Matthias Madler ◽  
Kanika Vanshylla ◽  
Ralf Eggeling ◽  
...  
Keyword(s):  
Public Health ◽  
Large Scale ◽  
Public Health Strategy ◽  
Site Testing ◽  
Testing Strategies ◽  
Health Strategy ◽  
Diagnostic Center ◽  
Positive Rate ◽  
Virus Culture ◽  
Culture Positive

The identification and isolation of highly infectious SARS-CoV-2-infected individuals is an important public health strategy. Rapid antigen detection tests (RADT) are promising candidates for large-scale screenings due to timely results and feasibility for on-site testing. Nonetheless, the diagnostic performance of RADT in detecting infectious individuals is yet to be fully determined. In this study, RT-qPCR and virus culture of RT-qPCR positive samples were used to evaluate and compare the performance of the Standard Q COVID-19 Ag Test in detecting SARS-CoV-2 infected and possibly infectious individuals. To this end, two combined oro- and nasopharyngeal swabs were collected at a routine SARS-CoV-2 diagnostic center. A total of 2,028 samples were tested and 118 virus cultures inoculated. SARS-CoV-2 infection was detected in 210 samples by RT-qPCR, representing a positive rate of 10.36%. The Standard Q COVID-19 Ag Test yielded a positive result in 92 (4.54%) samples resulting in an overall sensitivity and specificity of 42.86% and 99.89%. For adjusted Ct values <20 (n=14), <25 (n=57), and <30 (n=88) the RADT reached sensitivities of 100%, 98.25%, and 88.64%, respectively. All 29 culture positive samples were detected by RADT. While overall sensitivity was low, Standard Q COVID-19 RADT reliably detected patients with high RNA loads. Additionally, negative RADT results fully corresponded with the lack of viral cultivability in Vero E6 cells. These results indicate that RADT can be a valuable tool for the detection of individuals that are likely to transmit SARS-CoV-2. RADT testing could therefore guide public health testing strategies to combat the COVID-19 pandemic.

scholarly journals Reliable assessment of in vitro SARS-CoV-2 infectivity by a Rapid Antigen Detection Test

2021 ◽  
Author(s):  
Michael Korenkov ◽  
Nareshkumar Poopalasingam ◽  
Matthias Madler ◽  
Kanika Vanshylla ◽  
Ralf Eggeling ◽  
...  
Keyword(s):  
Public Health ◽  
Large Scale ◽  
Antigen Detection ◽  
Live Virus ◽  
Rapid Antigen Detection Test ◽  
Reliable Assessment ◽  
Health Strategy ◽  
Diagnostic Center ◽  
Positive Rate

The identification and isolation of highly infectious SARS-CoV-2-infected individuals is an important public health strategy. Rapid antigen detection tests (RADT) are promising candidates for large-scale screenings due to timely results and feasibility for on-site testing. Nonetheless, the diagnostic performance of RADT in detecting infectious individuals is yet to be fully determined. Two combined oro- and nasopharyngeal swabs were collected from individuals at a routine SARS-CoV-2 diagnostic center. Side-by-side evaluations of RT-qPCR and RADT as well as live virus cultures of positive samples were performed to determine the sensitivity of the Standard Q COVID-19 Ag Test (SD Biosensor/Roche) in detecting SARS-CoV-2-infected individuals with cultivable virus. A total of 2,028 samples were tested and 118 virus cultures inoculated. SARS-CoV-2 infection was detected in 210 samples by RT-qPCR, representing a positive rate of 10.36%. The Standard Q COVID-19 Ag Test yielded a positive result in 92 (4.54%) samples resulting in an overall sensitivity and specificity of 42.86% and 99.89%. For adjusted Ct values <20, <25, and <30 the RADT reached sensitivities of 100%, 98.15%, and 88.64%, respectively. All 29 culture positive samples were detected by RADT. While overall sensitivity was low, Standard Q COVID-19 RADT reliably detected patients with high RNA loads. Additionally, negative RADT results fully corresponded with the lack of viral cultivability in Vero E6 cells. These results indicate that RADT can be a valuable tool for the detection of individuals that are likely to transmit SARS-CoV-2. RADT testing could therefore guide public health testing strategies to combat the COVID-19 pandemic.

scholarly journals Application of a public health strategy to large-scale point-of-care screening for sickle cell disease in rural sub-Saharan Africa

2018 ◽  
Vol 2 (Supplement_1) ◽  
pp. 1-3 ◽  
Author(s):  
C. Chunda-Liyoka ◽  
A. A. Kumar ◽  
P. Sambo ◽  
F. Lubinda ◽  
L. Nchimba ◽  
...  
Keyword(s):  
Public Health ◽  
Sickle Cell Disease ◽  
Large Scale ◽  
Point Of Care ◽  
Sub Saharan Africa ◽  
Public Health Strategy ◽  
Cell Disease ◽  
Health Strategy ◽  
Scale Point ◽  
Sub Saharan

scholarly journals Adoption of local public health plan for better health and quality of life in Belgrade

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
G Tamburkovski ◽  
G Belamarić ◽  
D Matijević ◽  
S Mladenović Janković
Keyword(s):  
Public Health ◽  
Local Government ◽  
Health Plan ◽  
Health Planning ◽  
City Council ◽  
Public Health Strategy ◽  
Public Health Planning ◽  
Health Strategy ◽  
Public Health Plan ◽  
The City

Abstract Issue Development of public health plan for the City of Belgrade, facilitate multisectoral participation and encourage local government to incorporate public health planning into integrated planning framework, including funding. Description of the Problem According to Public Health Low, adopted in Serbia in 2016 and Public health strategy (2018), Council for Health, as a professional body of the City government, was obliged to prepare draft of the Plan. Members of the City Council are representatives from different sectors: health care, public health, private sector, child care, education and civil society. Based on data and information from relevant institutions and organizations, situation analysis and health profile of the City have been prepared during 2018. Results Public health plan for the City of Belgrade has been drafted for a time period from 2020 to 2026, aligned and within time frame of the National public health strategy. Plan included: mission, vision, objectives, activities, responsible institutions, funding sources and indicators for monitoring. Focus was on health promotion and empowerment of citizens to adopt healthy lifestyle as well on investment in environmental sustainability, poverty and inequalities reduction and minimizing risks to human health and well-being. On December 2019, Belgrade City Assembly adopted this document, with full responsibility for implementation and budgeting specific programs and projects from 2020. Lessons Multisectoral working group, with clear defined scope of work, supported by regulations, encouraged and managed by experts in the field, highly motivated to be creator of changes is prerequisite for successful and productive public health planning process. Key messages Public health planning enabled communication and cooperation among experts and decision makers and represented a whole-of-local government approach to public health. Document is used as a resource and model for the other cities and municipalities.

scholarly journals Staple crops biofortified with increased vitamins and minerals: considerations for a public health strategy

2016 ◽  
Vol 1390 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Maria Nieves Garcia-Casal ◽  
Juan Pablo Peña-Rosas ◽  
Boitshepo Giyose ◽  
Keyword(s):  
Public Health ◽  
Public Health Strategy ◽  
Health Strategy ◽  
Staple Crops

Consultancy in a national strategy

2013 ◽  
pp. 474-481
Author(s):  
Charles Guest
Keyword(s):  
Public Health ◽  
National Strategy ◽  
Public Health Strategy ◽  
Government Officials ◽  
Health Strategy ◽  
The Creation

This chapter introduces the steps for developing a public health strategy. It should assist you to play a constructive role as a public health consultant, working closely with government officials, policy advisers, and other stakeholders in the creation of a major strategy.

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