scholarly journals High Prevalence of M184 Mutation among Patients with Viroimmunologic Discordant Responses to Highly Active Antiretroviral Therapy and Outcomes after Change of Therapy Guided by Genotypic Analysis

2003 ◽  
Vol 41 (7) ◽  
pp. 3007-3012 ◽  
Author(s):  
E. Nicastri ◽  
L. Sarmati ◽  
G. d'Ettorre ◽  
S. G. Parisi ◽  
L. Palmisano ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Genotypic Analysis ◽  
High Prevalence

scholarly journals High Prevalence of Echocardiographic Abnormalities among HIV-infected Persons in the Era of Highly Active Antiretroviral Therapy

2010 ◽  
Vol 52 (3) ◽  
pp. 378-386 ◽  
Author(s):  
K. E. Mondy ◽  
J. Gottdiener ◽  
E. T. Overton ◽  
K. Henry ◽  
T. Bush ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
High Prevalence

scholarly journals Changes in Lipid Profiles and Other Biochemical Parameters in HIV-1 Infected Patients Newly Commenced on HAART Regimen

2013 ◽  
Vol 6 ◽  
pp. IDRT.S10044 ◽  
Author(s):  
Ballah Akawu Denue ◽  
Mohammed Bashir Alkali ◽  
Ali Usman Abjah ◽  
Ibrahim Musa Kida ◽  
Babajide Ajayi ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Serum Lipid ◽  
Biochemical Parameters ◽  
Lipid Profiles ◽  
Lipid Disorders ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
High Prevalence ◽  
Treatment Naïve

Abnormalities of lipid metabolism are common in human immunodeficiency virus (HIV)-infected patients and tend to be accentuated in those receiving antiretroviral therapy, particularly with protease inhibitors (PIs). However, there is a dearth of information on serum lipid profiles and biochemical parameters among treatment-naive HIV-positive patients in our environment. We found that after 24 months of highly active antiretroviral therapy (HAART), there was a significant increase in serum lipids. After 24 months of HAART, renal impairment was associated with a low increase in mean HDL and a high increase in triglycerides (TG). In conclusion, abnormality of serum lipid is common and showed female preponderance among treatment-naive HIV patients in our environment. Patients with HIV infection on HAART should be screened for lipid disorders given their high prevalence as observed in this study, because of its potential for morbidity and mortality in patients on HAART.

scholarly journals Analysis of HIV- type 1 protease and reverse transcriptase in Brazilian children failing highly active antiretroviral therapy (HAART)

2005 ◽  
Vol 47 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Daisy Maria Machado ◽  
Silvana Cláudia Fernandes ◽  
Regina Célia de Menezes Succi ◽  
Wilton Santos Freire ◽  
Cláudio Sérgio Pannuti ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Reverse Transcriptase ◽  
Highly Active Antiretroviral Therapy ◽  
Genotypic Resistance ◽  
Highly Active ◽  
Drug Classes ◽  
Antiretroviral Drug ◽  
Genotypic Analysis

The aim of this study was to evaluate the genotypic resistance profiles of HIV-1 in children failing highly active antiretroviral therapy (HAART). Forty-one children (median age = 67 months) receiving HAART were submitted to genotypic testing when virological failure was detected. cDNA was extracted from PBMCs and amplified by nested PCR for the reverse transcriptase and protease regions of the pol gene. Drug resistance genotypes were determined from DNA sequencing. According to the genotypic analysis, 12/36 (33.3%) and 6/36 (16.6%) children showed resistance and possible resistance, respectively, to ZDV; 5/36 (14%) and 4/36 (11.1%), respectively, showed resistance and possible resistance to ddI; 4/36 (11.1%) showed resistance to 3TC and D4T; and 3/36 (8.3%) showed resistance to Abacavir. A high percentage (54%) of children exhibited mutations conferring resistance to NNRTI class drugs. Respective rates of resistance and possible resistance to PIs were: RTV (12.2%, 7.3%); APV (2.4%, 12.1%); SQV(0%, 12.1%); IDV (14.6%, 4.9%), NFV (22%, 4.9%), LPV/RTV (2.4%, 12.1%). Overall, 37/41 (90%) children exhibited virus with mutations related to drug resistance, while 9% exhibited resistance to all three antiretroviral drug classes.

Opportunistic infections after the initiation of highly active antiretroviral therapy in advanced AIDS patients in an area with a high prevalence of tuberculosis

AIDS ◽  
2003 ◽  
Vol 17 (14) ◽  
pp. 2129-2131 ◽  
Author(s):  
Somnuek Sungkanuparph ◽  
Asda Vibhagool ◽  
Piroon Mootsikapun ◽  
Ploenchan Chetchotisakd ◽  
Somsit Tansuphaswaswadikul ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Opportunistic Infections ◽  
Aids Patients ◽  
Highly Active ◽  
High Prevalence
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