Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells
Nef-specific CD8+T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensivenefvariation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef165–173IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.
2012 ◽
Vol 513
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pp. 223-228
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2013 ◽
Vol 288
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pp. 32797-32808
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2000 ◽
Vol 74
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pp. 9256-9266
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2002 ◽
Vol 76
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pp. 633-643
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2020 ◽
2018 ◽