scholarly journals Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule.

1992 ◽  
Vol 66 (4) ◽  
pp. 2527-2531 ◽  
Author(s):  
Y Yanagi ◽  
A Tishon ◽  
H Lewicki ◽  
B A Cubitt ◽  
M B Oldstone
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
T Cell Receptors ◽  
Complex Molecule ◽  
Major Histocompatibility Complex Molecule ◽  
Major Histocompatibility ◽  
Cell Receptors ◽  
Histocompatibility Complex

Antigen-Specific, Major Histocompatibility Complex-Restricted T Cell Receptors

1983 ◽  
Vol 76 (1) ◽  
pp. 131-145 ◽  
Author(s):  
P. Marrack ◽  
C. Hannum ◽  
M. Harris ◽  
K. Haskins ◽  
R. Kubo ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
T Cell Receptors ◽  
Major Histocompatibility ◽  
Cell Receptors ◽  
Histocompatibility Complex

scholarly journals The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Philippa Marrack ◽  
Sai Harsha Krovi ◽  
Daniel Silberman ◽  
Janice White ◽  
Eleanor Kushnir ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
T Cell Receptors ◽  
Cell Receptor ◽  
Structural Basis ◽  
Major Histocompatibility ◽  
Cell Receptors ◽  
Histocompatibility Complex

Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long been debated. Here, using mice expressing one of two different T cell receptor β chains and various MHC alleles, we show that positive selection-induced MHC bias of T cell receptors is affected both by the germline encoded elements of the T cell receptor α and β chain and, surprisingly, dramatically affected by the non germ line encoded portions of CDR3 of the T cell receptor α chain. Thus, in addition to determining specificity for antigen, the non germline encoded elements of T cell receptors may help the proteins cope with the extremely polymorphic nature of major histocompatibility complex products within the species.

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