Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat.

1995 ◽  
Vol 69 (10) ◽  
pp. 6572-6576 ◽  
Author(s):  
C Suñé ◽  
M A García-Blanco
Keyword(s):  
Human Immunodeficiency Virus ◽  
Transcription Factor ◽  
Long Terminal Repeat ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Terminal Repeat ◽  
Sp1 Transcription Factor ◽  
Immunodeficiency Virus

scholarly journals Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides

2002 ◽  
Vol 76 (23) ◽  
pp. 12349-12354 ◽  
Author(s):  
Jason J. Coull ◽  
Guocheng He ◽  
Christian Melander ◽  
Victor C. Rucker ◽  
Peter B. Dervan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Long Terminal Repeat ◽  
Histone Deacetylase ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Terminal Repeat ◽  
Direct Access ◽  
Immunodeficiency Virus

ABSTRACT The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.

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