scholarly journals A Recombinant Measles Virus Expressing Hepatitis B Virus Surface Antigen Induces Humoral Immune Responses in Genetically Modified Mice

1999 ◽  
Vol 73 (6) ◽  
pp. 4823-4828 ◽  
Author(s):  
Mahender Singh ◽  
Roberto Cattaneo ◽  
Martin A. Billeter
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Surface Antigen ◽  
Measles Virus ◽  
Genetically Modified ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
B Virus ◽  
Genetically Modified Mice

ABSTRACT It has been shown previously that measles virus (MV) can be successfully used to express foreign proteins (M. Singh and M. A. Billeter, J. Gen. Virol. 80:101–106, 1998). To develop an inexpensive MV-based vaccine, we generated recombinant MVs that produce structural proteins of hepatitis B virus (HBV). A recombinant virus that expressed the HBV small surface antigen (HBsAg) was analyzed in terms of its replication characteristics, its genetic stability in cell culture, and its immunogenic potential in genetically modified mice. Although this virus showed a progression of replication slightly slower than that of the parental MV, it appeared to stably maintain the added genetic information; it uniformly expressed the appropriately glycosylated HBsAg after 10 serial passages. Genetically modified mice inoculated with this recombinant MV produced humoral immune responses against both HBsAg and MV proteins.

A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice

Vaccine ◽  
2013 ◽  
Vol 31 (8) ◽  
pp. 1197-1203 ◽  
Author(s):  
Pascale Buchmann ◽  
Claudia Dembek ◽  
Larissa Kuklick ◽  
Clemens Jäger ◽  
Raindy Tedjokusumo ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Transgenic Mice ◽  
Immune Responses ◽  
Hepatitis B Vaccine ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
B Virus ◽  
Novel Therapeutic

Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen

2014 ◽  
Vol 21 (12) ◽  
pp. 860-872 ◽  
Author(s):  
M. Jiang ◽  
R. Broering ◽  
M. Trippler ◽  
L. Poggenpohl ◽  
M. Fiedler ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Surface Antigen ◽  
Toll Like Receptor ◽  
Virus Surface ◽  
Virus Surface Antigen ◽  
B Virus

scholarly journals Mo1538 Hepatitis B Virus Surface Antigen Suppresses Innate and Adaptive Immune Responses of Murine and Human Liver Cells

2012 ◽  
Vol 142 (5) ◽  
pp. S-990
Author(s):  
Min Jiang ◽  
Martin Trippler ◽  
Ruth Bröring ◽  
Lena Poggenpohl ◽  
Guido Gerken ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Surface Antigen ◽  
Human Liver ◽  
Adaptive Immune Responses ◽  
Virus Surface ◽  
Adaptive Immune ◽  
Human Liver Cells ◽  
B Virus

In vitro immune responses to hepatitis B surface antigen (pre-S2 and S) following remote infection by hepatitis B virus in humans

1989 ◽  
Vol 9 (3) ◽  
pp. 229-241 ◽  
Author(s):  
Thomas R. Cupps ◽  
Jay H. Hoofnagle ◽  
Ronald W. Ellis ◽  
William J. Miller ◽  
Leonard Seeff ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Remote Infection ◽  
B Virus
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