RNA Interference Directed against Poly(ADP-Ribose) Polymerase 1 Efficiently Suppresses Human Immunodeficiency Virus Type 1 Replication in Human Cells
2004 ◽
Vol 78
(16)
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pp. 8931-8934
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Keyword(s):
Parp 1
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ABSTRACT We established small interfering RNA (siRNA) directed against poly(ADP-ribose) polymerase 1 (PARP-1) that effectively reduces the expression of PARP-1 in two human cell lines. Established siRNA against PARP-1 significantly suppressed human immunodeficiency virus type 1 (HIV-1) replication, as well as the activation of the integrated HIV-1 long terminal repeat promoter. These results indicate that PARP-1 is required for efficient HIV-1 replication in human cells. We propose that PARP-1 may serve as a cellular target for RNA interference-mediated gene silencing to inhibit HIV-1 replication.
2002 ◽
Vol 76
(18)
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pp. 9225-9231
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2004 ◽
Vol 78
(5)
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pp. 2601-2605
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2003 ◽
Vol 77
(21)
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pp. 11531-11535
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2006 ◽
Vol 80
(6)
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pp. 2855-2862
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2002 ◽
Vol 76
(24)
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pp. 12963-12973
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2005 ◽
Vol 79
(1)
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pp. 176-183
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2003 ◽
Vol 22
(4)
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pp. 281-286
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