RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2
2005 ◽
Vol 79
(14)
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pp. 9341-9345
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ABSTRACT We investigated the mechanism of resistance to genital herpes simplex virus type 2 (HSV-2) infection in mice transfected with the murine alpha-1 interferon (IFN-α1) transgene. In situ transfection of mice with the IFN-α1 transgene resulted in an elevation in an IFN-responsive gene, RNA-dependent protein kinase (PKR), but not 2′,5′-oligoadenylate synthetases (OAS), in vaginal tissue. Coupled with the finding that mice lacking a functional PKR pathway were no longer resistant to genital HSV-2 infection following transfection with the IFN-α1 transgene in comparison to wild-type mice or mice lacking a functional OAS pathway, these results suggest that PKR is the dominant antiviral pathway activated by the IFN-α1 transgene.
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2003 ◽
Vol 41
(11)
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pp. 5212-5214
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2002 ◽
Vol 46
(10)
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pp. 707-719
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2020 ◽
Vol 198
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pp. 106200
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2005 ◽
Vol 81
(4)
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pp. 303-305
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2001 ◽
Vol 50
(2)
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pp. 87-104
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