scholarly journals SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

mBio ◽  
2021 ◽  
Author(s):  
Yongzhen Liu ◽  
Chao Qin ◽  
Youliang Rao ◽  
Chau Ngo ◽  
Joshua J. Feng ◽  
...  
Keyword(s):  
Immune Evasion ◽  
Molecular Basis ◽  
Antiviral Agents ◽  
Subsequent Development ◽  
Innate Immune ◽  
Host Cells ◽  
Main Protease ◽  
Molecule Inhibitor ◽  
Innate Immune Evasion

The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral agents provides new avenues to prevent and treat COVID-19 diseases. This study describes a molecular characterization of innate immune evasion mediated by the SARS-CoV-2 Nsp5 main protease and subsequent development of a small-molecule inhibitor.

scholarly journals Innate immune evasion by filoviruses

Virology ◽  
2015 ◽  
Vol 479-480 ◽  
pp. 122-130 ◽  
Author(s):  
Christopher F. Basler
Keyword(s):  
Immune Evasion ◽  
Innate Immune ◽  
Innate Immune Evasion

scholarly journals Backbone resonance assignments of innate immune evasion protein EapH2 from the S. aureus

2019 ◽  
Vol 13 (1) ◽  
pp. 219-222 ◽  
Author(s):  
Alvaro I. Herrera ◽  
Abhinav Dubey ◽  
Brian V. Geisbrecht ◽  
Haribabu Arthanari ◽  
Om Prakash
Keyword(s):  
Immune Evasion ◽  
Resonance Assignments ◽  
Innate Immune ◽  
Backbone Resonance Assignments ◽  
Backbone Resonance ◽  
Innate Immune Evasion

scholarly journals Borrelia burgdorferi Resistance to a Major Skin Antimicrobial Peptide Is Independent of Outer Surface Lipoprotein Content

2009 ◽  
Vol 53 (10) ◽  
pp. 4490-4494 ◽  
Author(s):  
Amit Sarkar ◽  
Kit Tilly ◽  
Philip Stewart ◽  
Aaron Bestor ◽  
James M. Battisti ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Antimicrobial Peptide ◽  
Immune Evasion ◽  
Essential Role ◽  
Potential Role ◽  
Innate Immune ◽  
Initial Stage ◽  
Mammalian Infection ◽  
Innate Immune Evasion

ABSTRACT We hypothesize a potential role for Borrelia burgdorferi OspC in innate immune evasion at the initial stage of mammalian infection. We demonstrate that B. burgdorferi is resistant to high levels (>200 μg/ml) of cathelicidin and that this antimicrobial peptide exhibits limited binding to the spirochetal outer membrane, irrespective of OspC or other abundant surface lipoproteins. We conclude that the essential role of OspC is unrelated to resistance to this component of innate immunity.

scholarly journals Plasticity in early immune evasion strategies of a bacterial pathogen

2018 ◽  
Vol 115 (16) ◽  
pp. E3788-E3797 ◽  
Author(s):  
Quentin Bernard ◽  
Alexis A. Smith ◽  
Xiuli Yang ◽  
Juraj Koci ◽  
Shelby D. Foor ◽  
...  
Keyword(s):  
Immune Evasion ◽  
Bacterial Pathogen ◽  
Surface Protein ◽  
Innate Immune ◽  
Serum Complement ◽  
Term Survival ◽  
Evasion Strategy ◽  
Innate Immune Evasion ◽  
Novel Therapeutic

Borrelia burgdorferiis one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown. Here we report a unique innate immune evasion strategy ofB. burgdorferi, orchestrated by a surface protein annotated as BBA57, through its modulation of multiple spirochete virulent determinants. BBA57 function is critical for early infection but largely redundant for later stages of spirochetal persistence, either in mammals or in ticks. The protein influences host IFN responses as well as suppresses multiple host microbicidal activities involving serum complement, neutrophils, and antimicrobial peptides. We also discovered a remarkable plasticity in BBA57-mediated spirochete immune evasion strategy because its loss, although resulting in near clearance of pathogens at the inoculum site, triggers nonheritable adaptive changes that exclude detectable nucleotide alterations in the genome but incorporate transcriptional reprograming events. Understanding the malleability in spirochetal immune evasion mechanisms that ensures their host persistence is critical for the development of novel therapeutic and preventive approaches to combat long-term infections like Lyme borreliosis.

Intracellular survival and innate immune evasion of Burkholderia cepacia : Improved understanding of quorum sensing‐controlled virulence factors, biofilm, and inhibitors

2020 ◽  
Vol 64 (2) ◽  
pp. 87-98 ◽  
Author(s):  
Pitchaipillai Sankar Ganesh ◽  
Sivakumar Vishnupriya ◽  
Jamuna Vadivelu ◽  
Vanitha Mariappan ◽  
Kumutha M. Vellasamy ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Virulence Factors ◽  
Immune Evasion ◽  
Burkholderia Cepacia ◽  
Intracellular Survival ◽  
Innate Immune ◽  
Innate Immune Evasion
Sign in / Sign up

Export Citation Format

Share Document