scholarly journals A Human T-Cell Lymphotropic Virus Type 1 Enhancer of Myc Transforming Potential Stabilizes Myc-TIP60 Transcriptional Interactions

2005 ◽  
Vol 25 (14) ◽  
pp. 6178-6198 ◽  
Author(s):  
Soumya Awasthi ◽  
Anima Sharma ◽  
Kasuen Wong ◽  
Junyu Zhang ◽  
Elizabeth F. Matlock ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Lymphoproliferative Disease ◽  
Microarray Gene Expression ◽  
Independent Manner ◽  
Atll Patient ◽  
Human T Cell ◽  
Transcriptional Activator Protein ◽  
T Cell Leukemogenesis

ABSTRACT The human T-cell lymphotropic virus type 1 (HTLV-1) infects and transforms CD4+ lymphocytes and causes adult T-cell leukemia/lymphoma (ATLL), an aggressive lymphoproliferative disease that is often fatal. Here, we demonstrate that the HTLV-1 pX splice-variant p30II markedly enhances the transforming potential of Myc and transcriptionally activates the human cyclin D2 promoter, dependent upon its conserved Myc-responsive E-box enhancer elements, which are associated with increased S-phase entry and multinucleation. Enhancement of c-Myc transforming activity by HTLV-1 p30II is dependent upon the transcriptional coactivators, transforming transcriptional activator protein/p434 and TIP60, and it requires TIP60 histone acetyltransferase (HAT) activity and correlates with the stabilization of HTLV-1 p30II/Myc-TIP60 chromatin-remodeling complexes. The p30II oncoprotein colocalizes and coimmunoprecipitates with Myc-TIP60 complexes in cultured HTLV-1-infected ATLL patient lymphocytes. Amino acid residues 99 to 154 within HTLV-1 p30II interact with the TIP60 HAT, and p30II transcriptionally activates numerous cellular genes in a TIP60-dependent or TIP60-independent manner, as determined by microarray gene expression analyses. Importantly, these results suggest that p30II functions as a novel retroviral modulator of Myc-TIP60-transforming interactions that may contribute to adult T-cell leukemogenesis.

scholarly journals Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity

2004 ◽  
Vol 78 (21) ◽  
pp. 11686-11695 ◽  
Author(s):  
Jean-Marie Peloponese ◽  
Hidekatsu Iha ◽  
Venkat R. K. Yedavalli ◽  
Akiko Miyazato ◽  
Yan Li ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Independent Manner ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) encodes a 40-kDa Tax phosphoprotein. Tax is a transcriptional activator which modulates expression of the viral long terminal repeat and transcription of many cellular genes. Because Tax is a critical HTLV-1 factor which mediates viral transformation of T cells during the genesis of adult T-cell leukemia, it is important to understand the processes which can activate or inactivate Tax function. Here, we report that ubiquitination of Tax is a posttranscriptional mechanism which regulates Tax function. We show that ubiquitination does not target Tax for degradation by the proteasome. Rather, ubiquitin addition modifies Tax in a proteasome-independent manner from an active to a less-active transcriptional form.

scholarly journals Delayed Seroconversion and Rapid Onset of Lymphoproliferative Disease After Transmission of Human T-Cell Lymphotropic Virus Type 1 From a Multiorgan Donor

2013 ◽  
Vol 57 (10) ◽  
pp. 1417-1424 ◽  
Author(s):  
I. Glowacka ◽  
K. Korn ◽  
S. A. Potthoff ◽  
U. Lehmann ◽  
H. H. Kreipe ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Rapid Onset ◽  
Lymphoproliferative Disease ◽  
Human T Cell

Pain, psychoaffective symptoms, and quality of life in human T cell lymphotropic virus type 1 (HTLV-1): a cross-sectional study

2021 ◽  
Author(s):  
Dislene Nascimento dos Santos ◽  
Katia Nunes Sá ◽  
Fernanda C. Queirós ◽  
Alaí Barbosa Paixão ◽  
Kionna Oliveira Bernardes Santos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
T Cell ◽  
Virus Type ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Human T Cell

scholarly journals Correlation between LTR point mutations and proviral load levels among Human T cell Lymphotropic Virus type 1 (HTLV-1) asymptomatic carriers

2011 ◽  
Vol 8 (1) ◽  
pp. 535 ◽  
Author(s):  
Walter K Neto ◽  
Antonio C Da-Costa ◽  
Ana Carolina S de Oliveira ◽  
Vanessa P Martinez ◽  
Youko Nukui ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Proviral Load ◽  
Point Mutations ◽  
Asymptomatic Carriers ◽  
Human T Cell

scholarly journals Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results

2017 ◽  
Vol 55 (9) ◽  
pp. 2838-2849 ◽  
Author(s):  
Madoka Kuramitsu ◽  
Tsuyoshi Sekizuka ◽  
Tadanori Yamochi ◽  
Sanaz Firouzi ◽  
Tomoo Sato ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Proviral Load ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

ABSTRACTWestern blotting (WB) for human T cell leukemia virus type 1 (HTLV-1) is performed to confirm anti-HTLV-1 antibodies detected at the initial screening of blood donors and in pregnant women. However, the frequent occurrence of indeterminate results is a problem with this test. We therefore assessed the cause of indeterminate WB results by analyzing HTLV-1 provirus genomic sequences. A quantitative PCR assay measuring HTLV-1 provirus in WB-indeterminate samples revealed that the median proviral load was approximately 100-fold lower than that of WB-positive samples (0.01 versus 0.71 copy/100 cells). Phylogenic analysis of the complete HTLV-1 genomes of WB-indeterminate samples did not identify any specific phylogenetic groups. When we analyzed the nucleotide changes in 19 HTLV-1 isolates from WB-indeterminate samples, we identified 135 single nucleotide substitutions, composed of four types, G to A (29%), C to T (19%), T to C (19%), and A to G (16%). In the most frequent G-to-A substitution, 64% occurred at GG dinucleotides, indicating that APOBEC3G is responsible for mutagenesis in WB-indeterminate samples. Moreover, interestingly, five WB-indeterminate isolates had nonsense mutations in Pol and/or Tax, Env, p12, and p30. These findings suggest that WB-indeterminate carriers have low production of viral antigens because of a combination of a low proviral load and mutations in the provirus, which may interfere with host recognition of HTLV-1 antigens.

Prevalence of Antibody to Human T Cell Leukemia Virus Type 1 (HTLV-I) in Populations of Ivory Coast, West Africa

1989 ◽  
Vol 160 (3) ◽  
pp. 363-370 ◽  
Author(s):  
M. Verdier ◽  
F. Denis ◽  
A. Sangare ◽  
F. Barin ◽  
G. Gershy-Damet ◽  
...  
Keyword(s):  
T Cell ◽  
West Africa ◽  
Virus Type ◽  
Ivory Coast ◽  
Leukemia Virus ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Calcium-mediated inhibition of phorbol ester and Tax trans-activation of the human T cell leukaemia virus type 1

1994 ◽  
Vol 75 (7) ◽  
pp. 1623-1631 ◽  
Author(s):  
K. F. T. Copeland ◽  
A. G. M. Haaksma ◽  
J. Goudsmit ◽  
J. L. Heeney
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Phorbol Ester ◽  
Cell Leukaemia ◽  
Leukaemia Virus ◽  
Human T Cell

Infective Dermatitis Associated With Human T-Cell Lymphotropic Virus Type 1 In A Child With Bronchiectasis

2013 ◽  
Vol 32 (6) ◽  
pp. 690-693 ◽  
Author(s):  
Kate Webb ◽  
Carol Hlela ◽  
Chris Scott ◽  
David M. le Roux ◽  
Marco Zampoli ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Human T Cell

scholarly journals Factors associated with pain in individuals infected by human T-cell lymphotropic virus type 1 (HTLV-1)

2017 ◽  
Vol 21 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Dislene N. dos Santos ◽  
Kionna O.B. Santos ◽  
Alaí B. Paixão ◽  
Rosana Cristina P. de Andrade ◽  
Davi T. Costa ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Factors Associated ◽  
Human T Cell
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