scholarly journals Recurrent Vulvovaginal Candidiasis: a Dynamic Interkingdom Biofilm Disease of Candida and Lactobacillus

mSystems ◽  
2021 ◽  
Author(s):  
Emily McKloud ◽  
Christopher Delaney ◽  
Leighann Sherry ◽  
Ryan Kean ◽  
Shanice Williams ◽  
...  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Treatment Options ◽  
Vulvovaginal Candidiasis ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Prevention And Treatment ◽  
Significant Burden

RVVC is a significant burden, both economically and for women's health, but its prevalence is poorly documented globally due to the levels of self-treatment. Identifying triggers for development and recurrence of VVC and the pathogenesis of the microbes involved could considerably improve prevention and treatment options for women with recurrent, azole-resistant cases.

scholarly journals A Complex Microbial Interplay Underlies Recurrent Vulvovaginal Candidiasis Pathobiology

mSystems ◽  
2021 ◽  
Author(s):  
Nicolas Papon ◽  
Patrick Van Dijck
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Vulvovaginal Candidiasis ◽  
Recent Issue ◽  
Recurrent Vulvovaginal Candidiasis

While extremely prevalent, painful, and difficult to treat, vulvovaginal candidiasis remains largely understudied in the field of women’s health. In a recent issue of mSystems , McKloud et al. (E.

scholarly journals Treating (Recurrent) Vulvovaginal Candidiasis with Medical-Grade Honey—Concepts and Practical Considerations

2021 ◽  
Vol 7 (8) ◽  
pp. 664
Author(s):  
Senna J. J. M. van Riel ◽  
Celine M. J. G. Lardenoije ◽  
Guy J. Oudhuis ◽  
Niels A. J. Cremers
Keyword(s):  
Candida Species ◽  
Treatment Options ◽  
Standard Of Care ◽  
Vulvovaginal Candidiasis ◽  
Controlled Clinical Trial ◽  
Immunomodulatory Activity ◽  
Current Standard ◽  
Vaginal Infections ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Medical Grade

Recurrent vulvovaginal candidiasis (RVVC) is a relapsing vaginal fungal infection caused by Candida species. The prevalence varies among age populations and can be as high as 9%. Treatment options are limited, and in 57% of the cases, relapses occur within six months after fluconazole maintenance therapy, which is the current standard of care. The pathogenesis of RVVC is multifactorial, and recent studies have demonstrated that the vaginal microenvironment and activity of the immune system have a strong influence on the disease. Medical-grade honey (MGH) has protective, antimicrobial, and immunomodulatory activity and forms a putative alternative treatment. Clinical trials have demonstrated that honey can benefit the treatment of bacterial and Candida-mediated vaginal infections. We postulate that MGH will actively fight ongoing infections; eradicate biofilms; and modulate the vaginal microenvironment by its anti-inflammatory, antioxidative, and immunomodulatory properties, and subsequently may decrease the number of relapses when compared to fluconazole. The MGH formulation L-Mesitran Soft has stronger antimicrobial activity against various Candida species than its raw honey. In advance of a planned randomized controlled clinical trial, we present the setup of a study comparing L-Mesitran Soft with fluconazole and its practical considerations.

scholarly journals Sertaconazole in the treatment of vulvovaginal candidiasis

2019 ◽  
pp. 94-98 ◽  
Author(s):  
Z. N. Efendieva
Keyword(s):  
Drug Resistance ◽  
Women’S Health ◽  
Women's Health ◽  
Vulvovaginal Candidiasis ◽  
Important Task ◽  
Safety And Efficacy

Vulvovaginal candidiasis today is one of the most pressing problems in the field of women’s health. However, the prevalence of Candida with formed drug resistance to fluconazole significantly complicates the treatment of this disease. Thus, the evaluation of the safety and efficacy of other antimycotic drugs becomes an important task in the fight against recurrent genital candidiasis. The article presents the data of international and domestic studies on the possibilities of using sertaconazole in the therapy of vulvovaginal candidiasis.

Labia minora hypertrophy: causes, impact on women’s health, and treatment options

2017 ◽  
Vol 28 (10) ◽  
pp. 1453-1461 ◽  
Author(s):  
Caterina Gulia ◽  
Andrea Zangari ◽  
Vito Briganti ◽  
Zhoobin H. Bateni ◽  
Alessandro Porrello ◽  
...  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Treatment Options ◽  
Labia Minora

scholarly journals Iron Therapeutics in Women’s Health: Past, Present, and Future

2020 ◽  
Vol 13 (12) ◽  
pp. 449
Author(s):  
Joel Mintz ◽  
Jackie Mirza ◽  
Eric Young ◽  
Kyle Bauckman
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Reproductive Tract ◽  
Treatment Options ◽  
Physiological Role ◽  
Female Reproductive Tract ◽  
Iron Regulation ◽  
Direct Result ◽  
Dual Nature ◽  
Targeted Interventions

Iron plays a unique physiological role in the maintenance of homeostasis and the pathological outcomes of the female reproductive tract. The dual nature of elemental iron has created an evolutionary need to tightly regulate its biological concentration. The female reproductive tract is particularly unique due to the constant cycle of endometrial growth and shedding, in addition to the potential need for iron transfer to a developing fetus. Here, iron regulation is explored in a number of physiologic states including the endometrial lining and placenta. While iron dysregulation is a common characteristic in many women’s health pathologies there is currently a lack of targeted therapeutic options. Traditional iron therapies, including iron replacement and chelation, are common treatment options for gynecological diseases but pose long term negative health consequences; therefore, more targeted interventions directed towards iron regulation have been proposed. Recent findings show potential benefits in a therapeutic focus on ferritin-hepcidin regulation, modulation of reactive oxygen species (ROS), and iron mediated cell death (ferroptosis). These novel therapeutics are the direct result of previous research in iron’s complex signaling pathway and show promise for improved therapy, diagnosis, and prognosis in women’s health.

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