Deficiency of Length-Dependent Activation of Contraction in the Cardiac Muscle of Rats with Heart Failure: Assessment of the Muscle Strip and Single Cell Levels

BIOPHYSICS ◽  
2018 ◽  
Vol 63 (3) ◽  
pp. 441-448 ◽  
Author(s):  
O. N. Lookin ◽  
Yu. L. Protsenko
Keyword(s):  
Heart Failure ◽  
Cardiac Muscle ◽  
Single Cell ◽  
Muscle Strip ◽  
Failure Assessment ◽  
Length Dependent Activation

scholarly journals Recent Advances in Single-Cell Profiling and Multispecific Therapeutics: Paving the Way for a New Era of Precision Medicine Targeting Cardiac Fibroblasts

2021 ◽  
Vol 23 (7) ◽  
Author(s):  
Sally Yu Shi ◽  
Xin Luo ◽  
Tracy M. Yamawaki ◽  
Chi-Ming Li ◽  
Brandon Ason ◽  
...  
Keyword(s):  
Heart Failure ◽  
Precision Medicine ◽  
Single Cell ◽  
Cardiac Fibroblasts ◽  
Rapid Development ◽  
Cardiac Fibroblast ◽  
New Era ◽  
Fibroblast Activation ◽  
Cell Gene Expression ◽  
The Way

Abstract Purpose of Review Cardiac fibroblast activation contributes to fibrosis, maladaptive remodeling and heart failure progression. This review summarizes the latest findings on cardiac fibroblast activation dynamics derived from single-cell transcriptomic analyses and discusses how this information may aid the development of new multispecific medicines. Recent Findings Advances in single-cell gene expression technologies have led to the discovery of distinct fibroblast subsets, some of which are more prevalent in diseased tissue and exhibit temporal changes in response to injury. In parallel to the rapid development of single-cell platforms, the advent of multispecific therapeutics is beginning to transform the biopharmaceutical landscape, paving the way for the selective targeting of diseased fibroblast subpopulations. Summary Insights gained from single-cell technologies reveal critical cardiac fibroblast subsets that play a pathogenic role in the progression of heart failure. Combined with the development of multispecific therapeutic agents that have enabled access to previously “undruggable” targets, we are entering a new era of precision medicine.

Pulmonary Hypertension in Advanced Heart Failure: Assessment and Management of the Failing RV and LV

2019 ◽  
Vol 16 (5) ◽  
pp. 119-129 ◽  
Author(s):  
Sriram D. Rao ◽  
Jonathan N. Menachem ◽  
Edo Y. Birati ◽  
Jeremy A. Mazurek
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Advanced Heart Failure ◽  
Failure Assessment

Candesartan in heart failure—assessment of reduction in mortality and morbidity (CHARM): Rationale and design

1999 ◽  
Vol 5 (3) ◽  
pp. 276-282 ◽  
Author(s):  
Karl Swedberg ◽  
Marc Pfeffer ◽  
Chris Granger ◽  
Peter Held ◽  
John Mcmurray ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mortality And Morbidity ◽  
Failure Assessment
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