Determination of gatifloxacin in drug formulations, human urine, and serum samples using energy transfer chemiluminescence coupled with flow-injection analysis

2014 ◽  
Vol 69 (3) ◽  
pp. 276-282 ◽  
Author(s):  
Ning Lian ◽  
Jiang Hong Tang ◽  
Xiang Hong He
Keyword(s):  
Energy Transfer ◽  
Flow Injection ◽  
Flow Injection Analysis ◽  
Human Urine ◽  
Drug Formulations ◽  
Serum Samples ◽  
Human Urine And Serum ◽  
Urine And Serum

Determination of the antibacterial norfloxacin in human urine and serum samples by solid-phase spectrofluorimetry

2001 ◽  
Vol 444 (2) ◽  
pp. 279-286 ◽  
Author(s):  
J.L Vı́lchez ◽  
O Ballesteros ◽  
J Taoufiki ◽  
G Sánchez-Palencia ◽  
A Navalón
Keyword(s):  
Human Urine ◽  
Solid Phase ◽  
Serum Samples ◽  
Human Urine And Serum ◽  
Urine And Serum

scholarly journals Subnanogram Determination of Aniracetam in Pharmaceutical Preparations and Biofluids by Flow Injection Analysis with Chemiluminescence Detection Based on Its Enhancement of the Myoglobin-Luminol Reaction

2011 ◽  
Vol 94 (5) ◽  
pp. 1461-1466
Author(s):  
Shao Xiaodong ◽  
Li Ying ◽  
Li Fagen ◽  
Liu Yangqin ◽  
Song Zhenghua
Keyword(s):  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Serum Samples ◽  
Reaction Conditions ◽  
Whole Process ◽  
Optimum Reaction ◽  
Human Urine And Serum ◽  
Flow Injection Chemiluminescence ◽  
Urine And Serum

Abstract A novel flow injection chemiluminescence method with a myoglobin-luminol system is described for determining aniracetam. Myoglobin-bound aniracetam produced a complex that catalyzed the chemiluminescence reaction between luminol and myoglobin, leading to fast chemiluminescence. The chemiluminescence intensity in the presence of aniracetam was remarkably enhanced compared with that in the absence of aniracetam. Under the optimum reaction conditions the chemiluminescence increment produced was proportional to the concentration of aniracetam in the range of 0.1–1000.0 ng/mL (R2 = 0.9992), with a detection limit of 0.03 ng/mL (3δ). At a flow rate of 2.0 mL/min, the whole process, including sampling and washing, could be completed in 0.5 min, offering a sampling efficiency of 120/h; the RSD was less than 3.0% (n = 5). The method was satisfactory for determination of aniracetam in pharmaceutical preparations and human urine and serum samples. A possible mechanism of the reaction is also discussed.

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