Design, Synthesis, and Anticancer Activity of New Derivatives of Thiazole and Imidazole

2020 ◽  
Vol 90 (12) ◽  
pp. 2350-2355
Author(s):  
I. M. El-Deen ◽  
E. H. Elsayed ◽  
M. El-Ahwany ◽  
M. S. Abd El-Azez
Keyword(s):  
Anticancer Activity ◽  
Design Synthesis ◽  
Derivatives Of

Design, Synthesis and Anticancer Activity of Arylketo alkyne Derivatives of 7-Azaindole-oxazole

2021 ◽  
pp. 100743
Author(s):  
A.M.S. Krishna ◽  
Hima Bindu Gandham ◽  
Krishna Reddy Valluru ◽  
N.S. Kameswara Rao ◽  
Gattu Sridhar ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Design Synthesis ◽  
Derivatives Of ◽  
Alkyne Derivatives

Design, Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4

2019 ◽  
Vol 89 (3) ◽  
pp. 499-504 ◽  
Author(s):  
V. Ragha Suma ◽  
R. Sreenivasulu ◽  
M. Subramanyam ◽  
K. Ram Mohan Rao
Keyword(s):  
Anticancer Activity ◽  
Design Synthesis ◽  
Amide Derivatives ◽  
Combretastatin A4 ◽  
Derivatives Of

The design, synthesis and anticancer activity of new nitrogen mustard derivatives of natural indole phytoalexin 1-methoxyspirobrassinol

Neoplasma ◽  
2009 ◽  
Vol 56 (4) ◽  
pp. 321-330 ◽  
Author(s):  
R. MEZENCEV ◽  
P. KUTSCHY ◽  
A. SALAYOVA ◽  
T. UPDEGROVE ◽  
J. McDONALD
Keyword(s):  
Anticancer Activity ◽  
Nitrogen Mustard ◽  
Design Synthesis ◽  
Derivatives Of

Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid

2017 ◽  
Vol 27 (17) ◽  
pp. 4128-4132 ◽  
Author(s):  
Wen Gu ◽  
Xiao-Yan Jin ◽  
Dong-Dong Li ◽  
Shi-Fa Wang ◽  
Xu-Bing Tao ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ursolic Acid ◽  
Design Synthesis ◽  
Oxadiazole Derivatives ◽  
Derivatives Of

Design, synthesis, anticancer activity and mechanism studies of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid

2022 ◽  
Author(s):  
Wen-Yan Wang ◽  
Zihui Yang ◽  
A-Liang Li ◽  
Qing-Song Liu ◽  
Yue Sun ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Ursolic Acid ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Anticancer Activities ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Derivatives Of ◽  
Mcf 7

A series of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid were designed, synthesized, and evaluated for their anticancer activities against four cancer cell lines (MCF-7, HeLa, HepG2, and A549) and a...

Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides

2019 ◽  
Vol 19 (13) ◽  
pp. 1093-1110 ◽  
Author(s):  
Adel A.H. Abdel Rahman ◽  
Ibrahim F. Nassar ◽  
Amira K.F. Shaban ◽  
Dina S. EL-Kady ◽  
Hanem M. Awad ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Liver ◽  
Docking Studies ◽  
Cyclin Dependent Kinase ◽  
Binding Interaction ◽  
Enzyme Active Site ◽  
Human Liver Cancer ◽  
Amino Derivatives ◽  
Activity Behavior ◽  
Derivatives Of

Background & Objective:New diaryl-substituted pyrimidinedione compounds, their thioxo derivatives as well as their bicyclic thiazole compounds were synthesized and characterized.Methods:The glycosylamino derivatives of the synthesized disubstituted derivatives of the pyrimidine scaffold were also prepared via reaction of the N3-amino derivatives with a number of monosaccharides followed by acetylation.Results:The anticancer activity of the synthesized compounds was studied against human liver cancer (HepG2) and RPE-1cell lines. Compounds 2a, 2b, 3a and 12 showed potent activities with IC50 results comparable to that of doxorubicin.Conclusion:Docking investigations into Cyclin-dependent kinase 2 (CDK-2) enzyme, a potential target for cancer medication, were also reported showing the possible binding interaction into the enzyme active site to support their activity behavior.

Design, Synthesis and Evaluation of Novel Derivatives of Orotic Acid Amide as Potent Glucokinase Activators

2017 ◽  
Vol 14 (3) ◽  
pp. 252-261 ◽  
Author(s):  
Leilei Zhang ◽  
Shengquan Hu ◽  
Lei Lei ◽  
Yuliang Zhang ◽  
Lijing Zhang ◽  
...  
Keyword(s):  
Orotic Acid ◽  
Acid Amide ◽  
Design Synthesis ◽  
Glucokinase Activators ◽  
Derivatives Of

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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