Reactions of Malononitrile Dimer with Isothiocyanates
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Abstract The reaction of 2-amino-1,1,3-tricyanopropene (malononitrile dimer) with isothiocyanates leads to 1-substituted 4,6-diamino-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitriles or 4,6-diamino-2-(phenylimino)-2H-thiopyran-3,5-dicarbonitrile, depending on the conditions. Quantum-chemical modeling of the IR spectra and reaction routes for the synthesized compounds was carried out. In silico predictive analysis of potential protein targets, compliance with bioavailability criteria, and ADMET parameters was performed.
2020 ◽
Vol 65
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pp. 76-80
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2014 ◽
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pp. 1937-1944
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2021 ◽
Vol 95
(11)
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pp. 2263-2272
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