Porous copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide and (2-hydroxyethyl) methacrylate. Study of sorption properties

Porous crosslinked copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide (HPMA) or (2-hydroxyethyl) methacrylate were prepared, and the relationship between their structure and the sorption of papain, bovine serumalbumin, chymotrypsinogen, pepsin, ovalbumin, insulin, novocain and oleandomycin were investigated. The presence of hydrophilic components in the gel structure makes possible additional interactions between sorbent and the compound sorbed. The occurrence of additional interactions (probably hydrogen bonds) is more pronounced with cation exchangers containing the (2-hydroxyethyl) methacrylate monomeric unit, which favourably affects the sorption of univalent organic cations but at the same time contributes to the denaturation of sorbed proteins. In contrast to univalent organic cations, cation exchangers containing the N-(2-hydroxypropyl) methacrylamide monomeric unit are more advantageous in the sorption of proteins, because due to the lower extent of additional interactions no irreversible denaturation of sorbed labile proteins takes place in this case.

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Porous copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide and (2-hydroxyethyl) methacrylate. Preparation, swelling and morphology

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19791925 ◽

1979 ◽

Vol 44 (6) ◽

pp. 1925-1930 ◽

Cited By ~ 1

Author(s):

Jiří Vacík ◽

Zdeněk Pelzbauer ◽

Nadezhda N. Kuznetsova ◽

Klavdia P. Papukova ◽

Larisa K. Shataeva ◽

...

Keyword(s):

Methacrylic Acid ◽

Crosslinking Agent ◽

Scanning Electron Microscopy Data ◽

Hydroxyethyl Methacrylate ◽

Electron Microscopy Data ◽

Bulk Weight ◽

Hydroxypropyl Methacrylamide ◽

Porous Copolymers ◽

Microscopy Data ◽

Porous Morphology

Porous copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide or (2-hydroxyethyl) methacrylate were prepared using 1,3,5-triacryloylhexahydrotriazine as the crosslinking agent. The copolymers were characterized by their swelling, bulk weight, and morphologically by scanning electron microscopy. Data thus obtained were used in the interpretation of the formation of different porous morphology, differing in the size and ordering of globules.

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The effect of pH and temperature on the electrical conductivity of membranes made of methacrylic acid copolymers

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19833071 ◽

1983 ◽

Vol 48 (11) ◽

pp. 3071-3078 ◽

Cited By ~ 8

Author(s):

Jiří Vacík ◽

Larisa K. Shataeva ◽

Irina A. Chernova ◽

Georgii V. Samsonov ◽

Jan Schauer ◽

...

Keyword(s):

Electrical Conductivity ◽

Ion Exchange ◽

Charge Carrier ◽

Methacrylic Acid ◽

Empirical Equation ◽

Specific Resistance ◽

Hydroxyethyl Methacrylate ◽

Hydroxypropyl Methacrylamide ◽

Carboxylic Groups ◽

Methacrylic Acid Copolymers

The specific resistance was measured of swollen homogeneous and heterogeneous ion-exchange membranes made of methacrylic acid copolymers with N-(2-hydroxypropyl)methacrylamide and of its copolymers with 2-hydroxyethyl methacrylate. In the case of copolymers of 2-hydroxyethyl methacrylate and methacrylic acid, an increase in the methacrylic acid content raises the specific resistance of the membrane if the carboxylic groups are not ionized. At the degree of neutralization 0.5 the dependence becomes a reverse one. In copolymers of N-(2-hydroxypropyl)methacrylamide with 50 and more per cent of methacrylic acid the specific resistance of the membrane increases with increasing content of methacrylic acid in the case of the nonionized form while remaining virtually unchanged in the ionized form. All the investigated copolymers of N-(2-hydroxypropyl)methacrylamide have a maximum on the curve describing the dependence of the specific resistance on pH. This pH coincides with pH at which the diffusion mobility of the charge carrier of Na+ is highest. The dependence of the specific resistance on temperature can be described in terms of an empirical equation ρT = ρ0e-bT.

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