Cytostatic 6-Arylpurine Nucleosides II. Synthesis of Sugar-Modified Derivatives: 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-Deoxy-β-D-ribofuranosyl)- and 9-(2,3-Dihydroxypropyl)-6-phenylpurines
2000 ◽
Vol 65
(11)
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pp. 1683-1697
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Keyword(s):
9-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-(4-substituted phenyl)purines, 9-(5-deoxy-β-D-ribofuranosyl)-6-(4-substituted phenyl)purines and 9-(2,3-dihydroxypropyl)-6-(4-substituted phenyl)purines were prepared by the Suzuki-Miyaura cross-coupling reactions of the corresponding protected 9-substituted 6-chloropurines with substituted phenylboronic acids followed by MeONa mediated deprotection. In contrast to the highly active 6-phenylpurine ribonucleosides, the title compounds did not show any considerable cytostatic activity.
2000 ◽
Vol 43
(9)
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pp. 1817-1825
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Keyword(s):
Keyword(s):
2014 ◽
Vol 10
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pp. 2821-2826
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2021 ◽
Vol 943
◽
pp. 121823
2020 ◽
Vol 646
(15)
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pp. 1336-1341
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Keyword(s):
2001 ◽
Vol 66
(25)
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pp. 8677-8681
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Keyword(s):