On the Conformation of Glycobilirubin
2003 ◽
Vol 68
(5)
◽
pp. 1007-1019
◽
Keyword(s):
The first optically active glycine conjugate 1 of a bilirubin was prepared in several steps from (S)-β-methylxanthobilirubic acid glycine conjugate 8. The latter was synthesized by reaction of benzyl glycinate tosylate with the mixed anhydride formed in the reaction of (S)-β-methylxanthobilirubic acid 6 with isobutyl chloroformate. Spectroscopic analysis of the circular dichroism spectra of 1 in various solvents, including aqueous buffer, indicate a conformational preference for the M-helical ridge-tile conformation, thus providing the first spectroscopic evidence on the conformation of glycobilirubins.
1984 ◽
Vol 57
(4)
◽
pp. 989-996
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1980 ◽
Vol 39
◽
pp. 243-247
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1980 ◽
Vol 45
(2)
◽
pp. 435-441
◽
1973 ◽
pp. 335
◽
Keyword(s):
Keyword(s):
1971 ◽
Vol 0
(0)
◽
pp. 3990-3992
◽
2015 ◽
Vol 25
(4)
◽
pp. 273-274
◽