Peptidergic control of coronary resistance vessels

2011 ◽  
Author(s):  
György L. Nádasy ◽  
Mária Szekeres ◽  
Balázs Sachs ◽  
Violetta Kékesi ◽  
László Hunyady ◽  
...  
Keyword(s):  
Coronary Resistance ◽  
Resistance Vessels

Impaired Endothelium-Dependent Vasodilation of Coronary Resistance Vessels Is Associated With Exercise-Induced Myocardial Ischemia

Circulation ◽  
1995 ◽  
Vol 91 (9) ◽  
pp. 2345-2352 ◽  
Author(s):  
Andreas M. Zeiher ◽  
Thomas Krause ◽  
Volker Schächinger ◽  
Jan Minners ◽  
Ernst Moser
Keyword(s):  
Myocardial Ischemia ◽  
Coronary Resistance ◽  
Resistance Vessels ◽  
Exercise Induced

Vasodilatory Effect of Pulsatile Pressure on Coronary Resistance Vessels

1996 ◽  
Vol 79 (5) ◽  
pp. 1039-1045 ◽  
Author(s):  
Masami Goto ◽  
Ed VanBavel ◽  
Maurice J.M.M. Giezeman ◽  
Jos A.E. Spaan
Keyword(s):  
Coronary Resistance ◽  
Vasodilatory Effect ◽  
Resistance Vessels ◽  
Pulsatile Pressure

scholarly journals Effects of Various Doses of Intracoronary Diltiazem on Coronary Resistance Vessels in Humans.

1995 ◽  
Vol 59 (12) ◽  
pp. 790-798 ◽  
Author(s):  
Masaharu Ishihara ◽  
Hikaru Sato ◽  
Hironobu Tateishi ◽  
Takuji Kawagoe ◽  
Yuji Shimatani ◽  
...  
Keyword(s):  
Coronary Resistance ◽  
Resistance Vessels

Changes in diastolic coronary resistance during submaximal exercise in conditioned dogs

1983 ◽  
Vol 54 (4) ◽  
pp. 1057-1062 ◽  
Author(s):  
I. Y. Liang ◽  
H. L. Stone
Keyword(s):  
Neural Activity ◽  
Coronary Flow ◽  
Myocardial Oxygen Consumption ◽  
Work Load ◽  
Aortic Pressure ◽  
Submaximal Exercise ◽  
Treadmill Running ◽  
Adrenergic Blockade ◽  
Coronary Resistance ◽  
Resistance Vessels

Diastolic coronary resistance (DCR) was studied in 10 conscious dogs in the untrained (UT) and partially trained (PT) condition. The PT regime consisted of treadmill running 5 days/wk for 4–5 wk. Left circumflex coronary flow, aortic pressure, and heart rate were measured, and diastolic coronary resistance (DCR) was calculated. Adrenergic blockade was achieved with propranolol (1 mg/kg, iv) (beta B) and phentolamine (1 mg/kg, iv) (alpha B). During submaximal exercise in the UT condition, DCR fell from a resting value of 3.84 +/- 0.24 Torr . ml-1 . min with increasing work load to 1.57 +/- 0.12 Torr . ml-1 . min at 6.4 km/h (speed)/16% (grade). The decrease in DCR during submaximal exercise was greater in the PT than in the UT condition. DCR following alpha-adrenergic blockade was not significantly changed in the UT and PT conditions (e.g., at 6.4 km/h (speed)/16% (grade), 1.10 +/- 0.141 vs. 1.03 +/- 0.107 Torr . ml-1 . min, whereas following beta-adrenergic blockade, DCR was larger in the UT compared with the PT condition (e.g., at 6.4 km/h (speed)/16% (grade), 2.03 +/- 0.091 vs. 1.73 +/- 0.073 Torr . ml-1 X min). Myocardial oxygen consumption was not significantly different in the PT and UT conditions, indicating no difference in metabolism with partial training. The present study suggests that during submaximal exercise in the PT condition there is a change in the neurogenic control of the coronary vasculature by a reduction in sympathetic neural activity on the coronary resistance vessels.

Vasodilatory capacity of coronary resistance vessels in dilated cardiomyopathy

1994 ◽  
Vol 127 (2) ◽  
pp. 376-381 ◽  
Author(s):  
Teruo Inoue ◽  
Yoshihiko Sakai ◽  
Shigenori Morooka ◽  
Terumi Hayashi ◽  
Kan Takayanagi ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Coronary Resistance ◽  
Resistance Vessels

scholarly journals Endothelin-1-induced constriction in the coronary resistance vessels and abdominal aorta of the guinea pig

1990 ◽  
Vol 5 (4) ◽  
pp. 206-211 ◽  
Author(s):  
Anne Folta ◽  
Irving G. Joshua ◽  
R. Clinton Webb
Keyword(s):  
Guinea Pig ◽  
Abdominal Aorta ◽  
Coronary Resistance ◽  
Endothelin 1 ◽  
Resistance Vessels

Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase

2006 ◽  
Vol 290 (4) ◽  
pp. H1617-H1623 ◽  
Author(s):  
Erion Qamirani ◽  
Habib M. Razavi ◽  
Xin Wu ◽  
Michael J. Davis ◽  
Lih Kuo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guanylyl Cyclase ◽  
Sodium Azide ◽  
Inward Rectifier ◽  
Intraluminal Pressure ◽  
Dependent Manner ◽  
Coronary Resistance ◽  
Resistance Vessels ◽  
Severe Hypotension ◽  
Coronary Arterioles

Sodium azide (NaN3), a potent vasodilator, causes severe hypotension on accidental exposure. Although NaN3 has been shown to increase coronary blood flow, the direct effect of NaN3 on coronary resistance vessels and the mechanism of the NaN3-induced response remain to be established. To address these issues without confounding influences from systemic parameters, subepicardial coronary arterioles were isolated from porcine hearts for in vitro study. Arterioles developed basal tone at 60 cmH2O intraluminal pressure and dilated acutely, in a concentration-dependent manner, to NaN3 (0.1 μM to 50 μM). The NaN3 response was not altered by the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester or endothelial removal. Neither inhibition of phosphoinositol 3-kinase and tyrosine kinases nor blockade of ATP-sensitive, Ca2+-activated, and voltage-dependent K+ channels affected NaN3-induced dilation. However, the vasomotor action of NaN3 was significantly attenuated in a similar manner by the inward rectifier K+ (KIR) channel inhibitor Ba2+, the Na+-K+ ATPase inhibitor ouabain, or the guanylyl cyclase inhibitor 1 H-[1,2,4]oxadiazolo[4,3,- a]quinoxalin-1-one (ODQ). Ba2+, in combination with either ouabain or ODQ, nearly abolished the vasodilatory response. However, there was no additive inhibition by combining ouabain and ODQ. The NaN3-mediated vasodilation was also attenuated by morin, an inhibitor of phosphatidylinositolphosphate (PIP) kinase, which can regulate KIR channel activity. With the use of whole cell patch-clamp methods, NaN3 acutely enhanced Ba2+-sensitive KIR current in isolated coronary arteriolar smooth muscle cells. Collectively, this study demonstrates that NaN3, at clinically toxic concentrations, dilates coronary resistance vessels via activation of both KIR channels and guanylyl cyclase/Na+-K+-ATPase in the vascular smooth muscle. The KIR channels appear to be modulated by PIP kinase.

scholarly journals Dilator actions of endothelin in coronary resistance vessels and the abdominal aorta of the guinea pig

Life Sciences ◽  
1989 ◽  
Vol 45 (26) ◽  
pp. 2627-2635 ◽  
Author(s):  
Anne Folta ◽  
Irving G. Joshua ◽  
R. Clinton Webb
Keyword(s):  
Guinea Pig ◽  
Abdominal Aorta ◽  
Coronary Resistance ◽  
Resistance Vessels
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