OP0171 Achievement of Remission of Inflammation in the Spine and Sacroiliac Joints Measured by Magnetic Resonance Imaging (MRI) in Patients with Axial Spondyloarthritis, and Associations Between MRI and Clinical Remission, Over 96 Weeks of Treatment with Certolizumab Pegol

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 134.2-135 ◽  
Author(s):  
J. Braun ◽  
W.P. Maksymowych ◽  
R. Landewé ◽  
X. Baraliakos ◽  
K.-G. Hermann ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Clinical Remission ◽  
Axial Spondyloarthritis ◽  
Certolizumab Pegol ◽  
Resonance Imaging ◽  
Sacroiliac Joints ◽  
Magnetic Resonance Imaging Mri

Detection of Erosions in Sacroiliac Joints of Patients with Axial Spondyloarthritis Using the Magnetic Resonance Imaging Volumetric Interpolated Breath-hold Examination

2019 ◽  
Vol 46 (11) ◽  
pp. 1445-1449 ◽  
Author(s):  
Xenofon Baraliakos ◽  
Florian Hoffmann ◽  
Xiaohu Deng ◽  
Yan-Yan Wang ◽  
Feng Huang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Structural Changes ◽  
Axial Spondyloarthritis ◽  
Linear Regression Analysis ◽  
Cartilage Defects ◽  
Breath Hold ◽  
Resonance Imaging ◽  
Sacroiliac Joints ◽  
Magnetic Resonance Imaging Mri

Objective.The volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) technique can visualize erosive cartilage defects in peripheral joints. We evaluated the ability of VIBE to detect erosions in sacroiliac joints (SIJ) of patients with axial spondyloarthritis (axSpA) compared to the established T1-weighted MRI sequence and computed tomography (CT).Methods.MRI (T1-weighted and VIBE) and CT scans of SIJ of 109 patients with axSpA were evaluated by 2 blinded readers based on SIJ quadrants (SQ). Erosions were defined according to Assessment of Spondyloarthritis international Society (ASAS) definitions. Scores were recorded if readers were in agreement.Results.Erosions were less frequently detected by CT (153 SQ) than by T1-weighted MRI (182 SQ; p = 0.008) and VIBE-MRI (199 SQ; p < 0.001 vs CT and p = 0.031 vs T1-weighted MRI). Taking CT as the gold standard, the sensitivity of VIBE-MRI (71.2%) was higher than that for T1-weighted MRI (63.4%), with similar specificity (87.3% vs 88%, respectively). In linear regression analysis, younger age was significantly associated with occurrence of erosions independently in VIBE-MRI (β = 0.384, p < 0.001) and T1-weighted MRI (β = 0.369, p < 0.001) compared to CT.Conclusion.The VIBE-MRI sequence was more sensitive than T1-weighted MRI in identifying erosive damage in the SIJ, especially in younger patients. This might be due to the ability of VIBE-MRI to identify structural changes in the cartilage that have not yet extended to the underlying bone, where CT seems to be superior.

Prognostic Significance of Magnetic Resonance Imaging Changes of the Sacroiliac Joints in Spondyloarthritis – A Followup Study

2010 ◽  
Vol 37 (8) ◽  
pp. 1718-1727 ◽  
Author(s):  
KAREN BERENTH MADSEN ◽  
BERIT SCHIØTTZ-CHRISTENSEN ◽  
ANNE GRETHE JURIK
Keyword(s):  
Magnetic Resonance Imaging ◽  
New York ◽  
Magnetic Resonance ◽  
Axial Spondyloarthritis ◽  
Prognostic Significance ◽  
Activity Score ◽  
Resonance Imaging ◽  
Sacroiliac Joints ◽  
Scoring Method ◽  
Magnetic Resonance Imaging Mri

Objective.To evaluate the prognostic significance of sacroiliac joint (SIJ) changes by magnetic resonance imaging (MRI) based on 2–7 years of followup of patients with axial spondyloarthritis (SpA).Methods.Ninety-four patients (50 women, 44 men) with axial SpA obtained MRI of the SIJ from 1998–2004. They were examined at followup after 25–95 months (mean 51), including MRI and radiography of the SIJ and the spine. The Danish scoring method was used to quantify the activity and chronic SIJ changes by MRI. The activity score included subchondral edema and/or enhancement, while chronic changes encompassed erosions and subchondral fatty marrow deposition (FMD).Results.The MR score values for chronic SIJ changes increased significantly during followup, and were most pronounced in HLA-B27-positive patients and patients fulfilling the modified New York criteria for ankylosing spondylitis (AS) at followup. SIJ activity scores ≥ 2, total chronic scores ≥ 1, erosion scores ≥ 1, and FMD scores ≥ 4 at baseline were significantly related to progression of chronic SIJ changes. Activity score values ≥ 3 at baseline had a sensitivity of 0.83, specificity of 0.75, and accuracy of 0.80 in relation to the presence of AS at followup. The similar values for total chronic SIJ scores ≥ 4 at baseline were 0.86, 0.75, and 0.82, respectively, and for erosion scores ≥ 2 they were 0.88, 0.75, and 0.83.Conclusion.The occurrence of manifest SIJ activity by MRI or chronic changes at baseline was related to progression of chronic changes and the presence of AS at followup.

Magnetic Resonance Imaging Compared to Conventional Radiographs for Detection of Chronic Structural Changes in Sacroiliac Joints in Axial Spondyloarthritis

2013 ◽  
Vol 40 (9) ◽  
pp. 1557-1565 ◽  
Author(s):  
Denis Poddubnyy ◽  
Inna Gaydukova ◽  
Kay-Geert Hermann ◽  
In-Ho Song ◽  
Hildrun Haibel ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
New York ◽  
Magnetic Resonance ◽  
Structural Changes ◽  
Axial Spondyloarthritis ◽  
Joint Space ◽  
Resonance Imaging ◽  
Sacroiliac Joints ◽  
Overall Performance ◽  
Subchondral Sclerosis

Objective.We investigated the performance of magnetic resonance imaging (MRI) compared to conventional radiographs for detection of chronic structural changes in the sacroiliac joints (SIJ) in patients with axial spondyloarthritis (SpA).Methods.We included 112 patients with definite axial SpA (68 with ankylosing spondylitis and 44 with nonradiographic axial SpA), for whom radiographs and MRI scans of the SIJ performed at the same time were available. Radiographs and MRI of the SIJ were scored for subchondral sclerosis (score 0–2), erosions (score 0–3), and joint space changes (score 0–5) in each SIJ. Readers provided an overall impression of the extent of damage according to the scoring system of the modified New York criteria.Results.In total, 224 SIJ from 112 patients were available for analysis. There was rather low agreement between MRI and radiographs concerning definite erosions of SIJ (κ = 0.11), moderate agreement for definite subchondral sclerosis (κ = 0.46) and definite joint space abnormalities (κ = 0.41), and almost perfect agreement for joint ankylosis (κ = 0.85). MRI demonstrated a good overall performance in detection of definite “chronic” sacroiliitis, with a sensitivity of 84% and a specificity of 61%. For sacroiliitis fulfilling the modified New York criteria, MRI had a sensitivity of 81% and a specificity of 64% using radiographs as the reference method.Conclusion.MRI demonstrated good overall performance for detection of chronic structural changes in the SIJ as compared to radiographs.

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