THU0244 The role of stem cell-like memory t cells in systemic lupus erythematosus

Leptin is an adipocytokine that plays a key role in the modulation of immune responses and the development and maintenance of inflammation. Circulating levels of leptin are elevated in systemic lupus erythematosus (SLE) patients, but it is not clear whether this association can reflect a direct influence of leptin on the propathogenic events that lead to SLE. To investigate this possibility, we compared the extent of susceptibility to SLE and lupus manifestations between leptin-deficient (ob/ob) and H2-matched leptin-sufficient (wild-type, WT) mice that had been treated with the lupus-inducing agent pristane. Leptin deficiency protected ob/ob mice from the development of autoantibodies and renal disease and increased the frequency of immunoregulatory T cells (Tregs) compared with leptin-sufficient WT mice. The role of leptin in the development of SLE was confirmed in the New Zealand Black (NZB) × New Zealand White (NZW)F1 (NZB/W) mouse model of spontaneous SLE, where elevated leptin levels correlated with disease manifestations and the administration of leptin accelerated development of autoantibodies and renal disease. Conversely, leptin antagonism delayed disease progression and increased survival of severely nephritic NZB/W mice. At the cellular level, leptin promoted effector T-cell responses and facilitated the presentation of self-antigens to T cells, whereas it inhibited the activity of regulatory CD4 T cells. The understanding of the role of leptin in modulating autoimmune responses in SLE can open possibilities of leptin-targeted therapeutic intervention in the disease.

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THU0285 Dalazatide, An Inhibitor of The Kv1.3 Channel on Activated Effector Memory T Cells, Has Immunotherapy Potential in Systemic Lupus Erythematosus

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.5866 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 290.1-290

Author(s):

A.M. Stevens ◽

M. Yuasa ◽

D. Peckham ◽

C. Olsen ◽

S.P. Iadonato ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

T Cells ◽

Lupus Erythematosus ◽

Memory T Cells ◽

Effector Memory ◽

Systemic Lupus ◽

Effector Memory T Cells ◽

Kv1.3 Channel

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The Role ofγδT Cells in Systemic Lupus Erythematosus

Journal of Immunology Research ◽

10.1155/2016/2932531 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 13

Author(s):

Meng Wu ◽

Jinhua Yang ◽

Xiaofeng Li ◽

Junwei Chen

Keyword(s):

Systemic Lupus Erythematosus ◽

T Cells ◽

Autoimmune Disease ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Multiple Organs ◽

Minor Population ◽

Neuronal Tissues ◽

A Minor

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the overproduction of autoantibodies against an array of nuclear and cytoplasmic antigens and affects multiple organs, such as the skin, joints, kidneys, and neuronal tissues. T cells have been recognized as important players in the development of SLE due to their functions in cytokine secretion, antigen presentation, and supporting B cells for antibody production.γδT cells are a minor population of T cells that play important roles in infection and tumor-associated disease. In recent years, the role ofγδT cells in autoimmune diseases has been investigated. In this review, we discussed the role ofγδT cells in the pathogenesis of SLE.

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